Grodner Camille, Henn Aurélia, Lelièvre Jean-Daniel, Gallien Sébastien
Hopitaux Universitaires Henri Mondor, Creteil, France.
Universite Paris-Est Creteil Val de Marne Faculte de medecine, Creteil, France.
BMJ Case Rep. 2016 Nov 21;2016:bcr2016217753. doi: 10.1136/bcr-2016-217753.
Buschke-Löwenstein tumour (BLT), also defined as giant condyloma acuminatum, is a rare exophytic tumour affecting the anogenital and perianal regions associated with human papillomavirus (HPV) infections, with a potential of malignant transformation and which is at a greater risk in T-cell mediated immunodeficient patients. Different therapeutic options, alone or in combination, have been reported for the treatment of BLT including local therapy but wide surgical local excision is however recommended as the most important therapeutic intervention. We report a case of a HIV-infected man who developed a voluminous pelvic BLT which disappeared progressively under antiretroviral therapy with no additional treatment, contemporary to an improvement of his immunity, highlighting the possible spontaneous reversibility of HPV-induced tumours in treated HIV infection.
Buschke-Löwenstein肿瘤（BLT），也被定义为巨大尖锐湿疣，是一种罕见的外生性肿瘤，累及肛门生殖器和肛周区域，与人乳头瘤病毒（HPV）感染相关，具有恶性转化的潜能，在T细胞介导的免疫缺陷患者中风险更高。已报道了单独或联合使用的不同治疗方案用于治疗BLT，包括局部治疗，但广泛的手术局部切除仍被推荐为最重要的治疗干预措施。我们报告了一例感染HIV的男性病例，他患有巨大的盆腔BLT，在接受抗逆转录病毒治疗且未进行额外治疗的情况下逐渐消失，同时他的免疫力有所改善，这突出了在接受治疗的HIV感染中HPV诱导的肿瘤可能具有自发可逆性。
