Procento G M, Pollack E D
Department of Biological Sciences, University of Illinois, Chicago 60680.
Brain Res Dev Brain Res. 1989 Jun 1;47(2):243-9. doi: 10.1016/0165-3806(89)90179-x.
Nerve fibers extending from spinal cord explants of triploid frog tadpoles were analyzed by time-lapse cinephotomicrography. The triploid neurites grew at a mean rate that seemed to reflect the increased chromosomal dosage and had maximal velocities that were several times greater than for diploid neurites. Concurrently, the time between alternating episodes of acceleration and deceleration in triploid neurite elongation phases was decreased. During a 24-h period, however, triploid neurites spent less time elongating with a net result of shorter travel distances than for diploid neurites. The data suggest that the genome is one level of nerve fiber growth control that can be manipulated by dosage alterations.
通过延时电影显微摄影术对三倍体蛙蝌蚪脊髓外植体伸出的神经纤维进行了分析。三倍体神经突以似乎反映染色体剂量增加的平均速率生长，其最大速度比二倍体神经突快几倍。同时，三倍体神经突伸长阶段加速和减速交替发作之间的时间缩短。然而，在24小时内，三倍体神经突伸长的时间较少，最终行程距离比二倍体神经突短。数据表明基因组是神经纤维生长控制的一个水平，可以通过剂量改变来操纵。
