Teo Jeanette W P, Tan Paul, La My-Van, Krishnan Prabha, Tee Nancy, Koh Tse Hsien, Deepak Rama Narayana, Tan Thean Yen, Jureen Roland, Lin Raymond T P
National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
National Public Health Laboratory, Ministry of Health, Singapore.
J Glob Antimicrob Resist. 2014 Jun;2(2):99-102. doi: 10.1016/j.jgar.2013.11.003. Epub 2013 Dec 6.
Trends in carbapenem-resistant Enterobacteriaceae (CRE) collected from hospitals nationwide in Singapore over 3 years are presented. Hospital isolates with imipenem or meropenem minimum inhibitory concentrations (MICs) of >1mg/L were sent to the National Public Health Laboratory for further investigation. A total of 400 CRE were submitted, 227 (56.8%) of which carried a carbapenemase gene. bla was the most common (130/400; 32.5%), followed by bla (bla) (55/400; 13.8%). Interestingly, four isolates bearing dual carbapenemase genes were also detected. KPC- and OXA-48-like-producing Klebsiella pneumoniae were fingerprinted by DiversiLab rep-PCR. Locally, KPC producers do not appear to have clonal dissemination. In contrast, OXA-48-like producers were found to have a greater degree of clustering than KPC producers.
本文呈现了新加坡全国医院在3年时间里收集到的耐碳青霉烯类肠杆菌科细菌（CRE）的趋势。亚胺培南或美罗培南最低抑菌浓度（MIC）>1mg/L的医院分离菌株被送往国家公共卫生实验室进行进一步调查。总共提交了400株CRE，其中227株（56.8%）携带碳青霉烯酶基因。bla是最常见的（130/400；32.5%），其次是bla（bla）（55/400；13.8%）。有趣的是，还检测到4株携带双碳青霉烯酶基因的分离株。通过DiversiLab重复聚合酶链反应对产KPC和OXA - 48样的肺炎克雷伯菌进行指纹图谱分析。在本地，产KPC菌株似乎没有克隆传播。相比之下，发现产OXA - 48样菌株比产KPC菌株具有更高程度的聚集性。
