Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China.
Musculoskeletal Research Laboratory, Department of Orthopaedics &Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Sci Rep. 2016 Nov 22;6:37428. doi: 10.1038/srep37428.
In the present study, the microstructure, mechanical property, castability, corrosion behavior and in vitro cytocompatibility of binary Ti-2X alloys with various alloying elements, including Ag, Bi, Ga, Ge, Hf, In, Mo, Nb, Sn and Zr, were systematically investigated, in order to assess their potential applications in dental field. The experimental results showed that all binary Ti‒2X alloys consisted entirely α-Ti phase. The tensile strength and microhardness of Ti were improved by adding alloying elements. The castability of Ti was significantly improved by separately adding 2 wt.% Bi, Ga, Hf, Mo, Nb, Sn and Zr. The corrosion resistance of Ti in both normal artificial saliva solution (AS) and extreme artificial saliva solution (ASFL, AS with 0.2 wt.% NaF and 0.3 wt.% lactic acid) has been improved by separately adding alloying elements. In addition, the extracts of studied Ti‒2X alloys produced no significant deleterious effect to both fibroblasts L929 cells and osteoblast-like MG63 cells, indicating a good in vitro cytocompatibility, at the same level as pure Ti. The combination of enhanced mechanical properties, castability, corrosion behavior, and in vitro cytocompatibility make the developed Ti‒2X alloys have great potential for future stomatological applications.
在本研究中，系统研究了具有不同合金元素（Ag、Bi、Ga、Ge、Hf、In、Mo、Nb、Sn 和 Zr）的二元 Ti-2X 合金的微观结构、力学性能、铸造性能、腐蚀行为和体外细胞相容性，以评估它们在牙科领域的潜在应用。实验结果表明，所有二元 Ti-2X 合金均完全由 α-Ti 相组成。通过添加合金元素，提高了 Ti 的拉伸强度和显微硬度。分别添加 2wt.%Bi、Ga、Hf、Mo、Nb、Sn 和 Zr 可显著提高 Ti 的铸造性能。分别添加合金元素可提高 Ti 在正常人工唾液溶液（AS）和极端人工唾液溶液（ASFL，AS 中含有 0.2wt.%氟化钠和 0.3wt.%乳酸）中的耐腐蚀性。此外，研究的 Ti-2X 合金的浸提液对成纤维细胞 L929 细胞和成骨样 MG63 细胞均无明显的有害作用，表明其具有良好的体外细胞相容性，与纯 Ti 水平相当。增强的机械性能、铸造性能、耐腐蚀性能和体外细胞相容性的结合使开发的 Ti-2X 合金具有巨大的未来口腔应用潜力。
