外泌体在细胞稳态保护中的作用。
Role of exosomes in the protection of cellular homeostasis.
作者信息
Desdín-Micó Gabriela, Mittelbrunn María
机构信息
a Instituto de Investigación del Hospital 12 de Octubre , Madrid , Spain.
出版信息
Cell Adh Migr. 2017 Mar 4;11(2):127-134. doi: 10.1080/19336918.2016.1251000. Epub 2016 Nov 22.
Abstract
Due to their ability to shuttle proteins, lipids and genetic material between distant cells, exosomes promote extensive phenotypic changes in recipient cells, modulating immune responses, cellular migration, cancer metastasis or the spreading of neurotoxic protein aggregates in neurodegenerative diseases. Besides intercellular communication, exosome biogenesis and secretion permit the rapid release of a selective repertoire of compounds, conferring cells with an additional mechanism to fight alterations in protein, lipid or RNA homeostasis during stress or pathological conditions. Here, we review the dual role of the different quality control mechanisms arising from the endolysosomal system and the diverse situations that control the decision between degradation or secretion. The crosstalk between exosome secretion and the different cellular degradation mechanisms confers an additional layer of protection to maintain cellular integrity and homeostasis in a number of physiological and pathological conditions.
摘要
由于外泌体能够在远距离细胞之间穿梭蛋白质、脂质和遗传物质，因此它们可促进受体细胞发生广泛的表型变化，调节免疫反应、细胞迁移、癌症转移或神经退行性疾病中神经毒性蛋白聚集体的扩散。除了细胞间通讯外，外泌体的生物发生和分泌还允许快速释放一组选择性的化合物，赋予细胞一种额外的机制，以应对应激或病理条件下蛋白质、脂质或RNA稳态的改变。在这里，我们综述了内溶酶体系统产生的不同质量控制机制的双重作用，以及控制降解或分泌决策的各种情况。外泌体分泌与不同细胞降解机制之间的相互作用为在多种生理和病理条件下维持细胞完整性和稳态提供了额外的保护层。
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