4-羟基壬烯醛介导的信号传导与衰老
4-hydroxynonenal-mediated signaling and aging.
作者信息
Zhang Hongqiao, Forman Henry Jay
机构信息
Andrus Gerontology Center of the Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089-0191, USA.
Andrus Gerontology Center of the Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089-0191, USA.
出版信息
Free Radic Biol Med. 2017 Oct;111:219-225. doi: 10.1016/j.freeradbiomed.2016.11.032. Epub 2016 Nov 20.
Abstract
4-Hydroxy-2-nonenal (HNE), one of the major α, β-unsaturated aldehydes produced during lipid peroxidation, is a potent messenger in mediating signaling pathways. Lipid peroxidation and HNE production appear to increase with aging. Although the cause and effect relation remains arguable, aging is associated with significant changes in diverse signaling events, characterized by enhanced or diminished responses of specific signaling pathways. In this review we will discuss how HNE may contribute to aging-related alterations of signaling pathways.
摘要
4-羟基-2-壬烯醛（HNE）是脂质过氧化过程中产生的主要α，β-不饱和醛之一，是介导信号通路的一种强效信使。脂质过氧化和HNE的产生似乎会随着衰老而增加。尽管因果关系仍存在争议，但衰老与多种信号事件的显著变化有关，其特征是特定信号通路的反应增强或减弱。在本综述中，我们将讨论HNE如何可能导致与衰老相关的信号通路改变。
相似文献
1
4-hydroxynonenal-mediated signaling and aging.
Free Radic Biol Med. 2017 Oct;111:219-225. doi: 10.1016/j.freeradbiomed.2016.11.032. Epub 2016 Nov 20.
2
The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling.
Free Radic Biol Med. 2015 May;82:137-46. doi: 10.1016/j.freeradbiomed.2015.01.007. Epub 2015 Jan 21.
3
Proatherogenic effects of 4-hydroxynonenal.
Free Radic Biol Med. 2017 Oct;111:127-139. doi: 10.1016/j.freeradbiomed.2016.12.038. Epub 2016 Dec 29.
4
Cancer growth regulation by 4-hydroxynonenal.
Free Radic Biol Med. 2017 Oct;111:226-234. doi: 10.1016/j.freeradbiomed.2017.01.030. Epub 2017 Jan 25.
5
Pro-apoptotic effects of lipid oxidation products: HNE at the crossroads of NF-κB pathway and anti-apoptotic Bcl-2.
Free Radic Biol Med. 2017 Oct;111:209-218. doi: 10.1016/j.freeradbiomed.2016.11.010. Epub 2016 Nov 10.
6
Antioxidants and HNE in redox homeostasis.
Free Radic Biol Med. 2017 Oct;111:87-101. doi: 10.1016/j.freeradbiomed.2016.11.033. Epub 2016 Nov 22.
7
Age-related alteration in HNE elimination enzymes.
Arch Biochem Biophys. 2021 Mar 15;699:108749. doi: 10.1016/j.abb.2020.108749. Epub 2021 Jan 5.
8
Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats.
Int Immunopharmacol. 2015 Dec;29(2):591-598. doi: 10.1016/j.intimp.2015.09.024. Epub 2015 Oct 3.
9
Regulation of NF-κB-induced inflammatory signaling by lipid peroxidation-derived aldehydes.
Oxid Med Cell Longev. 2013;2013:690545. doi: 10.1155/2013/690545. Epub 2013 Apr 17.
10
Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE).
J Cell Physiol. 2012 Nov;227(11):3556-65. doi: 10.1002/jcp.24057.
引用本文的文献
1
Oxidative stress and programmed cell death in diabetic wounds: A comprehensive review.
Sci Prog. 2025 Jul-Sep;108(3):368504251370676. doi: 10.1177/00368504251370676. Epub 2025 Aug 18.
2
Cannabidiol improves learning and memory deficits and alleviates anxiety in 12-month-old SAMP8 mice.
PLoS One. 2025 Aug 14;20(8):e0296586. doi: 10.1371/journal.pone.0296586. eCollection 2025.
3
Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice.
Commun Med (Lond). 2025 Jun 10;5(1):222. doi: 10.1038/s43856-025-00942-3.
4
Ferroptosis in idiopathic pulmonary fibrosis: mechanisms, impact, and therapeutic opportunities.
Front Immunol. 2025 May 21;16:1567994. doi: 10.3389/fimmu.2025.1567994. eCollection 2025.
5
Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation.
Cell Death Discov. 2025 Apr 3;11(1):134. doi: 10.1038/s41420-025-02398-9.
6
Chronic Oral D-Galactose Induces Oxidative Stress but Not Overt Organ Dysfunction in Male Wistar Rats.
Curr Issues Mol Biol. 2025 Feb 27;47(3):161. doi: 10.3390/cimb47030161.
7
Oxidative Stress-mediated Lipid Peroxidation-derived Lipid Aldehydes in the Pathophysiology of Neurodegenerative Diseases.
Curr Neuropharmacol. 2025;23(6):671-685. doi: 10.2174/011570159X342720241014164650.
8
Asian Flush Gene Variant Enhances Cellular Immunogenicity of COVID-19 Vaccine: Prospective Observation in the Japanese General Population.
Vaccines (Basel). 2024 Sep 5;12(9):1015. doi: 10.3390/vaccines12091015.
9
Glucose-dependent insulinotropic polypeptide (GIP) alleviates ferroptosis in aging-induced brain damage through the Epac/Rap1 signaling pathway.
BMB Rep. 2024 Sep;57(9):417-423. doi: 10.5483/BMBRep.2024-0067.
10
Ten "Cheat Codes" for Measuring Oxidative Stress in Humans.
Antioxidants (Basel). 2024 Jul 22;13(7):877. doi: 10.3390/antiox13070877.
本文引用的文献
1
Redox homeostasis: The Golden Mean of healthy living.
Redox Biol. 2016 Aug;8:205-15. doi: 10.1016/j.redox.2016.01.010. Epub 2016 Jan 19.
2
4-Hydroxy-nonenal-A Bioactive Lipid Peroxidation Product.
Biomolecules. 2015 Sep 30;5(4):2247-337. doi: 10.3390/biom5042247.
3
Oxidative stress response and Nrf2 signaling in aging.
Free Radic Biol Med. 2015 Nov;88(Pt B):314-336. doi: 10.1016/j.freeradbiomed.2015.05.036. Epub 2015 Jun 9.
4
mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy.
Neurobiol Dis. 2015 Dec;84:39-49. doi: 10.1016/j.nbd.2015.03.014. Epub 2015 Mar 19.
5
mTOR: a pharmacologic target for autophagy regulation.
J Clin Invest. 2015 Jan;125(1):25-32. doi: 10.1172/JCI73939. Epub 2015 Jan 2.
6
On the role of 4-hydroxynonenal in health and disease.
Biochim Biophys Acta. 2015 May;1852(5):826-38. doi: 10.1016/j.bbadis.2015.01.015. Epub 2015 Jan 30.
7
The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling.
Free Radic Biol Med. 2015 May;82:137-46. doi: 10.1016/j.freeradbiomed.2015.01.007. Epub 2015 Jan 21.
8
Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria.
Redox Biol. 2015;4:193-9. doi: 10.1016/j.redox.2014.12.011. Epub 2014 Dec 29.
9
Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.
J Mol Cell Cardiol. 2014 Dec;77:42-52. doi: 10.1016/j.yjmcc.2014.09.022. Epub 2014 Sep 28.
10
Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases.
Aging Dis. 2014 Jun 1;5(3):203-11. doi: 10.14336/AD.2014.0500203. eCollection 2014 Jun.
Zotero 插件