4-羟基壬烯醛介导的信号传导与衰老
4-hydroxynonenal-mediated signaling and aging.
作者信息
Zhang Hongqiao, Forman Henry Jay
机构信息
Andrus Gerontology Center of the Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089-0191, USA.
Andrus Gerontology Center of the Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089-0191, USA.
出版信息
Free Radic Biol Med. 2017 Oct;111:219-225. doi: 10.1016/j.freeradbiomed.2016.11.032. Epub 2016 Nov 20.
Abstract
4-Hydroxy-2-nonenal (HNE), one of the major α, β-unsaturated aldehydes produced during lipid peroxidation, is a potent messenger in mediating signaling pathways. Lipid peroxidation and HNE production appear to increase with aging. Although the cause and effect relation remains arguable, aging is associated with significant changes in diverse signaling events, characterized by enhanced or diminished responses of specific signaling pathways. In this review we will discuss how HNE may contribute to aging-related alterations of signaling pathways.
摘要
4-羟基-2-壬烯醛（HNE）是脂质过氧化过程中产生的主要α，β-不饱和醛之一，是介导信号通路的一种强效信使。脂质过氧化和HNE的产生似乎会随着衰老而增加。尽管因果关系仍存在争议，但衰老与多种信号事件的显著变化有关，其特征是特定信号通路的反应增强或减弱。在本综述中，我们将讨论HNE如何可能导致与衰老相关的信号通路改变。
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