Goodland Monica N, Banerjee Subhashis, Niehoff Michael L, Young Benjamin J, Macarthur Heather, Butler Andrew A, Morley John E, Farr Susan A
Deparment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Institute for Translational Neuroscience, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
PLoS One. 2025 Aug 14;20(8):e0296586. doi: 10.1371/journal.pone.0296586. eCollection 2025.
Cannabidiol (CBD) has gained a lot of interest in recent years for its purported medicinal properties. CBD has been investigated for the treatment of anxiety, depression, epilepsy, neuroinflammation, and pain. Recently there has been an interest in CBD as a possible treatment for age-related disorders such as Alzheimer's disease and related disorders (ADRD). Here we tested the hypothesis that chronic CBD administration would improve learning and memory in the SAMP8 mouse model of Alzheimer's disease. SAMP8 mice aged 11 months (at the start of the study) were administered vehicle or CBD (3 or 30 mg/Kg) daily via oral gavage for 2 months. Vehicle-treated young SAMP8 mice (age 3 months at the start of the study) served as unimpaired controls. After 30 days of treatment (4 and 12 months of age), learning and memory, activity, anxiety, strength and dexterity were assessed. High dose CBD treatment significantly improved learning and memory of the 12-month-old mice in the T maze. Novel object recognition memory was also improved by CBD in aged CBD treated mice. Aged CBD treated mice also displayed less anxiety in the elevated plus maze test compared to controls. However, activity and strength levels were similar between groups. Biochemical analysis revealed decreased markers of oxidative stress, providing a possible mechanism by which CBD treatment impacts learning, memory, and anxiety. These results highlight the potential use of CBD as a therapeutic for age related cognitive impairment and dementia.
近年来，大麻二酚（CBD）因其所谓的药用特性而备受关注。人们对CBD治疗焦虑、抑郁、癫痫、神经炎症和疼痛进行了研究。最近，人们对CBD作为治疗阿尔茨海默病和相关疾病（ADRD）等与年龄相关疾病的可能疗法产生了兴趣。在此，我们检验了一个假设，即长期给予CBD会改善阿尔茨海默病SAMP8小鼠模型的学习和记忆能力。11个月大（研究开始时）的SAMP8小鼠通过口服灌胃每天给予赋形剂或CBD（3或30毫克/千克），持续2个月。用赋形剂处理的年轻SAMP8小鼠（研究开始时3个月大）作为未受损对照。治疗30天后（4个月和12个月大时），评估学习和记忆、活动、焦虑、力量和灵活性。高剂量CBD治疗显著改善了12个月大小鼠在T迷宫中的学习和记忆能力。在老年CBD处理的小鼠中，CBD也改善了新物体识别记忆。与对照组相比，老年CBD处理的小鼠在高架十字迷宫试验中也表现出较少的焦虑。然而，各组之间的活动和力量水平相似。生化分析显示氧化应激标志物减少，这为CBD治疗影响学习、记忆和焦虑提供了一种可能的机制。这些结果突出了CBD作为治疗与年龄相关认知障碍和痴呆症的潜在用途。
