抑郁症患者在奖励与损失过程中的腹侧纹状体功能连接及症状学
Ventral Striatum Functional Connectivity during Rewards and Losses and Symptomatology in Depressed Patients.
作者信息
Quevedo Karina, Ng Rowena, Scott Hannah, Kodavaganti Srivastava, Smyda Garry, Diwadkar Vaibhav, Phillips Mary
机构信息
University of Minnesota, Department of Psychiatry, MN, USA.
University of Minnesota, Institute of Child Development, 51 East River Road, Minneapolis, MN, 55455, USA.
出版信息
Biol Psychol. 2017 Feb;123:62-73. doi: 10.1016/j.biopsycho.2016.11.004. Epub 2016 Nov 19.
BACKGROUND
The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressed patients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment.
METHODS
38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner. Functional connectivity differences were examined with seeds in the Left or Right VS. FC estimates were regressed on specific symptoms.
RESULTS
Depressed patients displayed higher functional connectivity between the VS and midline cortical areas during loss versus reward trials. Anhedonia and depressed mood were associated to fairly similar striatal circuits but suicidality was associated to a unique VS-midline structures coupling, while depression severity was linked to higher VS to caudate and precuneus connectivity during loss versus reward trials.
CONCLUSIONS
Depression is characterized by excessive VS coupling to cognitive control and associative networks during losses versus rewards. High VS to midline cortical structures coupling may index suicidality.
背景
腹侧纹状体（VS）及纹状体网络支持目标导向行为。确定抑郁症患者在处理情绪显著事件时其纹状体网络有何不同，是朝着揭示诊断和治疗生物标志物迈出的一步。
方法
38名抑郁症患者和30名健康成年人完成了一项任务，该任务检测了大脑对预期和获得金钱奖励及损失的激活情况。使用3T西门子Trio扫描仪收集数据。用左侧或右侧VS中的种子点检查功能连接差异。功能连接估计值针对特定症状进行回归分析。
结果
在损失与奖励试验中，抑郁症患者的VS与中线皮质区域之间表现出更高的功能连接。快感缺乏和抑郁情绪与相当相似的纹状体回路相关，但自杀倾向与独特的VS-中线结构耦合相关，而抑郁严重程度与损失与奖励试验期间VS与尾状核及楔前叶的更高连接相关。
结论
抑郁症的特征是在损失与奖励期间，VS与认知控制及联想网络过度耦合。VS与中线皮质结构的高耦合可能指示自杀倾向。
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