Yee C, Biondi A, Wang X H, Iscove N N, de Sousa J, Aarden L A, Wong G G, Clark S C, Messner H A, Minden M D
Department of Medicine and Medical Biophysics, Ontario Cancer Institute, Toronto, Canada.
Blood. 1989 Aug 1;74(2):798-804.
Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secretion of IL-6 by two lymphoma cell lines, OCI-LY3 and OCI-LY12. Addition of recombinant IL-6 stimulated their growth, whereas addition of polyclonal anti-recombinant IL-6 (anti-rIL-6) had a marked inhibitory effect on proliferation. These results suggest an autocrine role for IL-6 in the growth of these lymphoma cells in culture.
