Kim Tae Hoon, Lee Jae Seung, Lee Sei Won, Oh Yeon-Mok
Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Int J Chron Obstruct Pulmon Dis. 2016 Nov 9;11:2785-2796. doi: 10.2147/COPD.S119372. eCollection 2016.
Postoperative pulmonary complications (PPCs) are one of the most important causes of postoperative morbidity and mortality after abdominal surgery. Although chronic obstructive pulmonary disease (COPD) has been considered a risk factor for PPCs, it remains unclear whether mild-to-moderate COPD is a risk factor. This retrospective cohort study included 387 subjects who underwent abdominal surgery with general anesthesia in a tertiary referral hospital. PPCs included pneumonia, pulmonary edema, pulmonary thromboembolism, atelectasis, and acute exacerbation of COPD. Among the 387 subjects, PPCs developed in 14 (12.0%) of 117 patients with mild-to-moderate COPD and in 13 (15.1%) of 86 control patients. Multiple logistic regression analysis revealed that mild-to-moderate COPD was not a significant risk factor for PPCs (odds ratio [OR] =0.79; 95% confidence interval [CI] =0.31-2.03; =0.628). However, previous hospitalization for respiratory problems (OR =4.20; 95% CI =1.52-11.59), emergency surgery (OR =3.93; 95% CI =1.75-8.82), increased amount of red blood cell (RBC) transfusion (OR =1.09; 95% CI =1.05-1.14 for one pack increase of RBC transfusion), and laparoscopic surgery (OR =0.41; 95% CI =0.18-0.93) were independent predictors of PPCs. These findings suggested that mild-to-moderate COPD may not be a significant risk factor for PPCs after abdominal surgery.
术后肺部并发症(PPCs)是腹部手术后发病和死亡的最重要原因之一。尽管慢性阻塞性肺疾病(COPD)被认为是PPCs的一个危险因素,但轻度至中度COPD是否为危险因素仍不清楚。这项回顾性队列研究纳入了一家三级转诊医院387例接受全身麻醉下腹部手术的患者。PPCs包括肺炎、肺水肿、肺血栓栓塞、肺不张和COPD急性加重。在这387例患者中,117例轻度至中度COPD患者中有14例(12.0%)发生了PPCs,86例对照患者中有13例(15.1%)发生了PPCs。多因素logistic回归分析显示,轻度至中度COPD不是PPCs的显著危险因素(比值比[OR]=0.79;95%置信区间[CI]=0.31-2.03;P=0.628)。然而,既往因呼吸问题住院(OR=4.20;95%CI=1.52-11.59)、急诊手术(OR=3.93;95%CI=1.75-8.82)、红细胞(RBC)输注量增加(每增加1单位RBC输注,OR=1.09;95%CI=1.05-1.14)和腹腔镜手术(OR=0.41;95%CI=0.18-0.93)是PPCs的独立预测因素。这些发现表明,轻度至中度COPD可能不是腹部手术后PPCs的显著危险因素。