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轻至中度慢性阻塞性肺疾病患者腹部手术后的肺部并发症

Pulmonary complications after abdominal surgery in patients with mild-to-moderate chronic obstructive pulmonary disease.

作者信息

Kim Tae Hoon, Lee Jae Seung, Lee Sei Won, Oh Yeon-Mok

机构信息

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

Int J Chron Obstruct Pulmon Dis. 2016 Nov 9;11:2785-2796. doi: 10.2147/COPD.S119372. eCollection 2016.

Abstract

Postoperative pulmonary complications (PPCs) are one of the most important causes of postoperative morbidity and mortality after abdominal surgery. Although chronic obstructive pulmonary disease (COPD) has been considered a risk factor for PPCs, it remains unclear whether mild-to-moderate COPD is a risk factor. This retrospective cohort study included 387 subjects who underwent abdominal surgery with general anesthesia in a tertiary referral hospital. PPCs included pneumonia, pulmonary edema, pulmonary thromboembolism, atelectasis, and acute exacerbation of COPD. Among the 387 subjects, PPCs developed in 14 (12.0%) of 117 patients with mild-to-moderate COPD and in 13 (15.1%) of 86 control patients. Multiple logistic regression analysis revealed that mild-to-moderate COPD was not a significant risk factor for PPCs (odds ratio [OR] =0.79; 95% confidence interval [CI] =0.31-2.03; =0.628). However, previous hospitalization for respiratory problems (OR =4.20; 95% CI =1.52-11.59), emergency surgery (OR =3.93; 95% CI =1.75-8.82), increased amount of red blood cell (RBC) transfusion (OR =1.09; 95% CI =1.05-1.14 for one pack increase of RBC transfusion), and laparoscopic surgery (OR =0.41; 95% CI =0.18-0.93) were independent predictors of PPCs. These findings suggested that mild-to-moderate COPD may not be a significant risk factor for PPCs after abdominal surgery.

摘要

术后肺部并发症(PPCs)是腹部手术后发病和死亡的最重要原因之一。尽管慢性阻塞性肺疾病(COPD)被认为是PPCs的一个危险因素,但轻度至中度COPD是否为危险因素仍不清楚。这项回顾性队列研究纳入了一家三级转诊医院387例接受全身麻醉下腹部手术的患者。PPCs包括肺炎、肺水肿、肺血栓栓塞、肺不张和COPD急性加重。在这387例患者中,117例轻度至中度COPD患者中有14例(12.0%)发生了PPCs,86例对照患者中有13例(15.1%)发生了PPCs。多因素logistic回归分析显示,轻度至中度COPD不是PPCs的显著危险因素(比值比[OR]=0.79;95%置信区间[CI]=0.31-2.03;P=0.628)。然而,既往因呼吸问题住院(OR=4.20;95%CI=1.52-11.59)、急诊手术(OR=3.93;95%CI=1.75-8.82)、红细胞(RBC)输注量增加(每增加1单位RBC输注,OR=1.09;95%CI=1.05-1.14)和腹腔镜手术(OR=0.41;95%CI=0.18-0.93)是PPCs的独立预测因素。这些发现表明,轻度至中度COPD可能不是腹部手术后PPCs的显著危险因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/686d/5108484/97d40455177c/copd-11-2785Fig1.jpg

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