Razina T G, Zueva E P, Ulrich A V, Rybalkina O Yu, Chaikovskii A V, Isaikina N V, Kalinkina G I, Zhdanov V V, Zyuz'kov G N
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
National Research Tomsk State University, Tomsk, Russia.
Bull Exp Biol Med. 2016 Nov;162(1):93-97. doi: 10.1007/s10517-016-3554-4. Epub 2016 Nov 23.
The effects of Fructus Sorbi aucupariae extract, originally saturated with anthocyans, on the development of Lewis lung carcinoma and B-16 melanoma in C57Bl/6 mice and the efficiency of cyclophosphamide treatment were studied. Antitumor activity of the extract and potentiation of the antimetastatic activity of the cytostatic were demonstrated. Studies on melanoma B-16 model revealed an increase in the counts of stromal progenitor cells in the tumor node and their accelerated maturation after treatment with the extract. No effects towards the tumor stem and committed cells were detected.
研究了最初富含花青素的花楸提取物对C57Bl/6小鼠Lewis肺癌和B-16黑色素瘤发展的影响以及环磷酰胺治疗的效果。证明了该提取物的抗肿瘤活性以及对细胞抑制剂抗转移活性的增强作用。对黑色素瘤B-16模型的研究显示，用该提取物处理后，肿瘤结节中基质祖细胞数量增加且其成熟加速。未检测到对肿瘤干细胞和定向分化细胞的影响。
