Gol'dberg E D, Amosova E N, Zueva E P, Razina T G, Krylova S G, Zorikov P S
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Bull Exp Biol Med. 2008 Feb;145(2):252-5. doi: 10.1007/s10517-008-0063-0.
Experiments on animals with Lewis lung carcinoma and Ehrlich tumor showed that licorice (glycyrrhiza) extract and glyciram prepared from this plant improved the antitumor effect of cyclophosphamide. Glyciram reduced the toxic effect of the cytostatic on peripheral blood leukocytes. Licorice extract inhibited the growth of Ehrlich tumor and development of metastases in mice with Lewis lung carcinoma. Glyciram administered to mice after removal of Lewis lung carcinoma produced an antimetastatic effect and prevented relapses.
对患有刘易斯肺癌和艾氏腹水瘤的动物进行的实验表明，甘草提取物以及从该植物制备的甘氨酰胺可增强环磷酰胺的抗肿瘤效果。甘氨酰胺降低了细胞抑制剂对外周血白细胞的毒性作用。甘草提取物可抑制艾氏腹水瘤的生长以及刘易斯肺癌小鼠体内转移灶的形成。在切除刘易斯肺癌后给小鼠施用甘氨酰胺可产生抗转移作用并预防复发。
