Goncharova N V, Khrapova M V, Pupyshev A B, Korolenko E Ts, Nešéáková Z, Korolenko T A
Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
University Canada West, Vancouver, Canada.
Bull Exp Biol Med. 2016 Nov;162(1):18-22. doi: 10.1007/s10517-016-3534-8. Epub 2016 Nov 23.
We studied biological effects of mannan, a polysaccharide immunomodulator from C. albicans, that interacts with mannose receptor in vivo. It is shown that preliminary administration of mannan (5 times in a dose of 50 mg/kg or 2 times in a dose of 100 mg/kg) to mice with acute lipemia induced by lipase inhibitor poloxamer 407 (300 mg/kg) reduces the serum concentrations of atherogenic LDL, cholesterol, and triglycerides. Administration of mannan to intact mice and animals with acute lipemia reduces triglyceride concentration and causes labilization of lysosomal membranes in the liver. Serum activity of chitotriosidase, a marker of macrophage activation, was elevated in mice with acute lipemia treated with mannan. Thus, mannan from C. albicans is a promising hypolipidemic polysaccharide compound, similar by its activity to β-glycan, a component of LPS.
我们研究了来自白色念珠菌的一种多糖免疫调节剂甘露聚糖在体内与甘露糖受体相互作用的生物学效应。结果表明，给用脂肪酶抑制剂泊洛沙姆407（300mg/kg）诱导急性脂血症的小鼠预先给予甘露聚糖（50mg/kg剂量给药5次或100mg/kg剂量给药2次），可降低致动脉粥样硬化的低密度脂蛋白、胆固醇和甘油三酯的血清浓度。给正常小鼠和急性脂血症动物施用甘露聚糖可降低甘油三酯浓度，并导致肝脏溶酶体膜不稳定。在用甘露聚糖治疗的急性脂血症小鼠中，巨噬细胞活化标志物壳三糖苷酶的血清活性升高。因此，来自白色念珠菌的甘露聚糖是一种有前景的降血脂多糖化合物，其活性与脂多糖的成分β-聚糖相似。
