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看不到尽头:美国老年人使用苯二氮䓬类药物的情况

No End in Sight: Benzodiazepine Use in Older Adults in the United States.

作者信息

Maust Donovan T, Kales Helen C, Wiechers Ilse R, Blow Frederic C, Olfson Mark

机构信息

Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.

Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan.

出版信息

J Am Geriatr Soc. 2016 Dec;64(12):2546-2553. doi: 10.1111/jgs.14379. Epub 2016 Nov 23.

DOI:10.1111/jgs.14379
PMID:27879984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5173408/
Abstract

OBJECTIVES

To establish the rate of new and continuation of benzodiazepine use in older adults seen by nonpsychiatrist physicians and to identify subpopulations at risk of new and continuation benzodiazepine use.

DESIGN

Cross-sectional analysis.

SETTING

National Ambulatory Medical Care Survey (2007-10).

PARTICIPANTS

Adults visiting office-based nonpsychiatrist physicians (n = 98,818) who were prescribed a benzodiazepine (new or continuation).

MEASUREMENTS

Percentage of benzodiazepine visits of all outpatient encounters according to patient age and corresponding annual visit rate per 1,000 population. Analysis was then limited to adults aged 65 and older, demographic, clinical, and visits characteristics were used to compare visits of benzodiazepine users with those of nonusers and visits of continuation users with those of new users.

RESULTS

The overall proportion of benzodiazepine visits ranged from 3.2% (95% confidence interval (CI) = 2.7-3.7) of those aged 18 to 34 to 6.6% (95% CI = 5.8-7.6) of those aged 80 and older, and the proportion of continuation visits increased with age, rising to 90.2% (95% CI = 86.2-93.1) of those aged 80 and older. The population-based visit rate ranged from 61.7 (95% CI = 50.7-72.7) per 1,000 persons in the youngest adults to 463.7 (95% CI = 385.4-542.0) in those aged 80 and older. Only 16.0% (95% CI = 13.5-18.8) of continuation users had any mental health diagnosis. Of all benzodiazepine users, fewer than 1% (95% CI = .4-1.8) were provided or referred to psychotherapy, and 10.0% (95% CI = 7. 2-13.3) were also prescribed an opioid.

CONCLUSION

In the United States, few older adult benzodiazepine users receive a clinical mental health diagnosis, and almost none are provided or referred to psychotherapy. Prescribing to older adults continues despite decades of evidence documenting safety concerns, effective alternative treatments, and effective methods for tapering even chronic users.

摘要

目的

确定非精神科医生诊治的老年人中苯二氮䓬类药物新使用者和持续使用者的比例,并识别有新使用和持续使用苯二氮䓬类药物风险的亚人群。

设计

横断面分析。

设置

国家门诊医疗调查(2007 - 2010年)。

参与者

就诊于非精神科医生办公室且被开具苯二氮䓬类药物(新使用或持续使用)的成年人(n = 98,818)。

测量指标

根据患者年龄计算所有门诊就诊中苯二氮䓬类药物就诊的百分比以及每1000人口相应的年就诊率。然后分析限于65岁及以上成年人,使用人口统计学、临床和就诊特征来比较苯二氮䓬类药物使用者与非使用者的就诊情况以及持续使用者与新使用者的就诊情况。

结果

苯二氮䓬类药物就诊的总体比例在18至34岁人群中为3.2%(95%置信区间(CI)= 2.7 - 3.7),在80岁及以上人群中为6.6%(95% CI = 5.8 - 7.6),且持续就诊的比例随年龄增加,在80岁及以上人群中升至90.2%(95% CI = 86.2 - 93.1)。基于人群的就诊率在最年轻成年人中为每1000人61.7(95% CI = 50.7 - 72.7),在80岁及以上人群中为463.7(95% CI = 385.4 -

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