妥舒沙星引起的结晶性肾病。

Crystalline nephropathy caused by tosufloxacin.

作者信息

Matsubara Risa, Kibe Tetsuya, Nomura Takemasa

机构信息

Department of Pediatrics, Seirei-Mikatahara General Hospital, Hamamatsu, Shizuoka, Japan.

出版信息

Pediatr Int. 2016 Nov;58(11):1219-1221. doi: 10.1111/ped.13116.

DOI:10.1111/ped.13116

PMID:27882736

Abstract

A 14-year-old girl was treated for 3 days with tosufloxacin (450 mg twice a day) for acute bronchitis and then developed acute kidney injury. Renal ultrasound showed enlarged kidneys without hydronephrosis. Urinalysis indicated drug crystal casts (2-3/HPF), consistent with drug-induced crystalline nephropathy. The patient recovered gradually with i.v. hydration and discontinuation of tosufloxacin, leading to the diagnosis of tosufloxacin crystalline nephropathy. Medical practitioners should be aware that crystalline nephropathy can occur in pediatric patients receiving tosufloxacin.

摘要

一名14岁女孩因急性支气管炎接受了3天的妥舒沙星治疗（每日两次，每次450毫克），随后出现急性肾损伤。肾脏超声显示肾脏增大，无肾积水。尿液分析显示有药物结晶管型（2 - 3/HPF），符合药物性结晶肾病。患者通过静脉补液和停用妥舒沙星后逐渐康复，从而确诊为妥舒沙星结晶肾病。医务人员应意识到，接受妥舒沙星治疗的儿科患者可能会发生结晶肾病。