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氟喹诺酮类药物相关性残疾的治疗：病理生物化学意义。

Treatment of the Fluoroquinolone-Associated Disability: The Pathobiochemical Implications.

机构信息

Physics Faculty, Laboratory of Vision Science and Optometry, Adam Mickiewicz University in Poznań, Umultowska Street 85, 61-614 Poznań, Poland.

Nanobiomedical Center of Poznań, Umultowska Street 85, 61-614 Poznań, Poland.

出版信息

Oxid Med Cell Longev. 2017;2017:8023935. doi: 10.1155/2017/8023935. Epub 2017 Sep 25.

DOI:10.1155/2017/8023935
PMID:29147464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5632915/
Abstract

Long-term fluoroquinolone-associated disability (FQAD) after fluoroquinolone (FQ) antibiotic therapy appears in recent years as a significant medical and social problem, because patients suffer for many years after prescribed antimicrobial FQ treatment from tiredness, concentration problems, neuropathies, tendinopathies, and other symptoms. The knowledge about the molecular activity of FQs in the cells remains unclear in many details. The effective treatment of this chronic state remains difficult and not effective. The current paper reviews the pathobiochemical properties of FQs, hints the directions for further research, and reviews the research concerning the proposed treatment of patients. Based on the analysis of literature, the main directions of possible effective treatment of FQAD are proposed: (a) reduction of the oxidative stress, (b) restoring reduced mitochondrion potential Δ,

摘要

长期氟喹诺酮相关性残疾（FQAD）在氟喹诺酮（FQ）抗生素治疗后近年来成为一个重要的医学和社会问题，因为患者在接受处方抗菌 FQ 治疗后多年会遭受疲劳、注意力问题、神经病变、腱病和其他症状的困扰。关于 FQs 在细胞中的分子活性的知识在许多细节上仍不清楚。这种慢性状态的有效治疗仍然很困难，且效果不佳。本文综述了 FQs 的病理生物化学特性，提示了进一步研究的方向，并回顾了有关患者治疗建议的研究。基于文献分析，提出了 FQAD 可能的有效治疗的主要方向：（a）减少氧化应激，（b）恢复降低的线粒体电位 Δ，

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c0e/5632915/fc36240620e9/OMCL2017-8023935.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c0e/5632915/54a34017e6b1/OMCL2017-8023935.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c0e/5632915/3dc06f2b5f0a/OMCL2017-8023935.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c0e/5632915/fc36240620e9/OMCL2017-8023935.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c0e/5632915/54a34017e6b1/OMCL2017-8023935.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c0e/5632915/3dc06f2b5f0a/OMCL2017-8023935.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c0e/5632915/fc36240620e9/OMCL2017-8023935.003.jpg

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