Letendre Paul, Monga Varun, Milhem Mohammed, Zakharia Yousef
Department of Hematology, Oncology & Blood & Marrow Transplantation & the Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
Future Oncol. 2017 Mar;13(7):625-636. doi: 10.2217/fon-2016-0385. Epub 2016 Nov 24.
The arsenal for the treatment of metastatic melanoma is limited. A new approach to therapy using checkpoint blockade has improved overall survival in this patient population. Ipilimumab a CTLA-4 monoclonal antibody is a first in class drug that has pioneered this revolution. In this review, the authors provide an account of the different stages that led to the development of ipilimumab, its approval in the clinical setting for the treatment of advanced melanoma and ongoing investigations of combinatorial immune therapy.
转移性黑色素瘤的治疗手段有限。一种使用检查点阻断的新治疗方法改善了该患者群体的总生存期。伊匹单抗,一种CTLA-4单克隆抗体,是引领这场革命的同类首创药物。在这篇综述中,作者阐述了伊匹单抗研发过程的不同阶段、其在临床环境中被批准用于治疗晚期黑色素瘤的情况以及正在进行的联合免疫治疗研究。