Chen L-K, Hwang A-C, Liu L-K, Lee W-J, Peng L-N
Prof Liang-Kung Chen, Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, No 201, Sec 2, Shih-Pai Road, Taipei, Taiwan, TEL: +886-2-28757830, FAX: +886-2-28757711, Email:
J Frailty Aging. 2016;5(4):208-213. doi: 10.14283/jfa.2016.109.
To evaluate the prevalence of frailty and the associated multimorbidity and functional impairments among community-dwelling middle-aged and elderly people in Taiwan.
a cross-sectional study.
communities in I-Lan County of Taiwan.
1839 community-dwelling people aged 50 years and older.
None.
Frailty defined by Fried's criteria, Charlson's comorbidity index (CCI), Functional Autonomy Measurement System (SMAF), Center for Epidemiologic Studies Depression Scale (CES-D), Mini-Nutrition Assessment (MNA), Mini-Mental State Examination (MMSE), and Short Form-12 quality of life questionnaire.
Overall, 1839 subjects (mean age: 63.9±9.3 years, 47.5% males) participated in this study and men were more likely to have higher educational level, more smoking and alcohol drinking habit. The prevalence of frailty was 6.8% in this study, while pre-frailty was 40.5% and 53.7% of all participants were robust. Compared to subjects with different frailty status, age, education year, alcohol drinking, hypertension, diabetes mellitus, hyperlipidemia, CCI, walking speed, handgrip strength, score of SMAF, CES-D, MNA, MMSE, quality of life were significantly different between groups (P all< 0.05). Older age, poorer physical function, poorer cognitive function, poorer nutritional status, more depressive symptoms, higher CCI and poorer quality of life were all independently associated with frailty.
Frailty was not simply a geriatric syndrome, but the combination of multiple geriatric syndromes. Further study is needed to evaluate the clinical benefits of intervention programs for community-dwelling middle-aged and older people to reverse frailty and its associated functional impairments.
评估台湾社区中老年居民中衰弱的患病率及其相关的多种疾病和功能障碍情况。
横断面研究。
台湾宜兰县的社区。
1839名年龄在50岁及以上的社区居民。
无。
采用弗里德标准定义衰弱，查尔森合并症指数（CCI）、功能自主测量系统（SMAF）、流行病学研究中心抑郁量表（CES-D）、微型营养评定法（MNA）、简易精神状态检查表（MMSE）以及简明健康调查量表12项生活质量问卷。
总体而言，1839名受试者（平均年龄：63.9±9.3岁，男性占47.5%）参与了本研究，男性更有可能具有较高的教育水平、更多的吸烟和饮酒习惯。本研究中衰弱的患病率为6.8%，而衰弱前期为40.5%，53.7%的参与者身体状况良好。与不同衰弱状态的受试者相比，年龄、受教育年限、饮酒、高血压、糖尿病、高脂血症、CCI、步行速度、握力、SMAF评分、CES-D评分、MNA评分、MMSE评分、生活质量在各组之间存在显著差异（所有P值均<0.05）。年龄较大、身体功能较差、认知功能较差、营养状况较差、抑郁症状较多、CCI较高以及生活质量较差均与衰弱独立相关。
衰弱并非简单的老年综合征，而是多种老年综合征的组合。需要进一步研究以评估针对社区中老年居民的干预项目在逆转衰弱及其相关功能障碍方面的临床益处。
