癌胚抗原相关基因在孕早期人胎盘中的表达。
Expression of CEA-related genes in the first trimester human placenta.
作者信息
McLenachan T, Mansfield B
机构信息
Department of Microbiology and Genetics, Massey University, Palmerston North, New Zealand.
出版信息
Biochem Biophys Res Commun. 1989 Aug 15;162(3):1486-93. doi: 10.1016/0006-291x(89)90842-5.
Eight cDNA clones, closely related to the carcino-embryonic antigen gene family, have been isolated from a cDNA library representing genes expressed in the first trimester human placenta. Sequence analysis of one clone shows it to be a pregnancy-specific beta 1-glycoprotein (PS beta G) closely related to three other PS beta G cDNA recently characterised from a term placenta library. The protein encoded by the cDNA is predicted to be less high glycosylated than those reported previously and differs markedly in the C-terminal sequence. The 3' untranslated region of the cDNA is very similar to the equivalent region of beta 1-glycoprotein PS beta G E except that it contains the 12bp repeat sequence found flanking the Alu sequence in CEa and an additional 67bp of sequence that appears to be derived from CEA.
从一个代表孕早期人胎盘表达基因的cDNA文库中，分离出了8个与癌胚抗原基因家族密切相关的cDNA克隆。对其中一个克隆的序列分析表明，它是一种妊娠特异性β1-糖蛋白（PSβG），与最近从足月胎盘文库中鉴定出的其他三种PSβG cDNA密切相关。预计该cDNA编码的蛋白质糖基化程度低于先前报道的蛋白质，并且在C端序列上有明显差异。该cDNA的3'非翻译区与β1-糖蛋白PSβG E的相应区域非常相似，只是它包含在CEa中Alu序列侧翼发现的12bp重复序列以及另外67bp似乎源自CEA的序列。
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