Rooney B C, Horne C H, Hardman N
Department of Biochemistry, University of Aberdeen, Marischal College, U.K.
Gene. 1988 Nov 30;71(2):439-49. doi: 10.1016/0378-1119(88)90061-3.
Human pregnancy-specific beta 1-glycoprotein (SP1) plays an essential role in normal pregnancy. It is also a well-characterized oncodevelopmental antigen, expressed aberrantly by all trophoblastic tumors and some other malignant cell types. Here we report the identification of a human placental cDNA encoding the SP1 polypeptide sequence. The coding sequence shows 95% identity at the nucleotide level with a distinct, recently published SP1 cDNA sequence (PSG16). Unexpectedly, the sequence is also highly homologous to the published sequence of human carcinoembryonic antigen (CEA). SP1, CEA and CEA-related nonspecific cross-reacting species thus belong to a group of closely related though antigenically diverse tumor-associated glycoproteins. Comparison of the deduced amino acid sequence of the SP1 cDNA with that of CEA provides insight into the modular nature of these related proteins. This may have implications for the genomic organization and evolution of the CEA gene family.
人妊娠特异性β1-糖蛋白（SP1）在正常妊娠中起着至关重要的作用。它也是一种特征明确的肿瘤发生发育抗原，在所有滋养层肿瘤和其他一些恶性细胞类型中异常表达。在此，我们报告了一个编码SP1多肽序列的人胎盘cDNA的鉴定。该编码序列在核苷酸水平上与一个不同的、最近发表的SP1 cDNA序列（PSG16）具有95%的同一性。出乎意料的是，该序列与人癌胚抗原（CEA）的已发表序列也高度同源。因此，SP1、CEA以及CEA相关的非特异性交叉反应物质属于一组密切相关但抗原性不同的肿瘤相关糖蛋白。将SP1 cDNA推导的氨基酸序列与CEA的氨基酸序列进行比较，有助于深入了解这些相关蛋白的模块性质。这可能对CEA基因家族的基因组组织和进化具有重要意义。
