海马体中空间编码背后的神经活动模式。
Neural Activity Patterns Underlying Spatial Coding in the Hippocampus.
作者信息
Sosa Marielena, Gillespie Anna K, Frank Loren M
机构信息
Kavli Institute for Fundamental Neuroscience and Department of Physiology, University of California, San Francisco, USA.
Howard Hughes Medical Institute, Maryland, USA.
出版信息
Curr Top Behav Neurosci. 2018;37:43-100. doi: 10.1007/7854_2016_462.
The hippocampus is well known as a central site for memory processing-critical for storing and later retrieving the experiences events of daily life so they can be used to shape future behavior. Much of what we know about the physiology underlying hippocampal function comes from spatial navigation studies in rodents, which have allowed great strides in understanding how the hippocampus represents experience at the cellular level. However, it remains a challenge to reconcile our knowledge of spatial encoding in the hippocampus with its demonstrated role in memory-dependent tasks in both humans and other animals. Moreover, our understanding of how networks of neurons coordinate their activity within and across hippocampal subregions to enable the encoding, consolidation, and retrieval of memories is incomplete. In this chapter, we explore how information may be represented at the cellular level and processed via coordinated patterns of activity throughout the subregions of the hippocampal network.
海马体作为记忆处理的核心部位广为人知，它对于存储和日后检索日常生活中的经历事件至关重要，从而使这些经历能够用于塑造未来的行为。我们对海马体功能背后生理学的许多了解都来自于对啮齿动物的空间导航研究，这些研究在理解海马体如何在细胞水平上表征经历方面取得了巨大进展。然而，要将我们对海马体空间编码的认识与它在人类和其他动物的记忆相关任务中所发挥的作用协调起来，仍然是一项挑战。此外，我们对于神经元网络如何在海马体亚区域内以及跨海马体亚区域协调它们的活动以实现记忆的编码、巩固和检索的理解并不完整。在本章中，我们将探讨信息如何在细胞水平上被表征，以及如何通过海马体网络各亚区域中协调的活动模式进行处理。
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