Nakaegawa Yuta, Nakamura Ryosuke, Tada Yasuhiro, Suzuki Ryo, Takezawa Toshiaki, Nakamura Tatsuo, Omori Koichi
a Department of Otolaryngology , Fukushima Medical University , Fukushima , Japan.
b Department of Otolaryngology, Head and Neck Surgery , Kyoto University , Kyoto , Japan.
Acta Otolaryngol. 2017 Jun;137(6):627-634. doi: 10.1080/00016489.2016.1257150. Epub 2016 Nov 25.
Tight fixation of the artificial trachea is important for epithelialization and tracheal stenosis.
The authors have developed an artificial trachea and have used it for tracheal reconstruction. Although various studies on tracheal reconstruction have been conducted, no studies have examined the effect of artificial tracheal fixation on tracheal stenosis and regeneration. Therefore, the purpose of the present study was to evaluate the effect of artificial tracheal fixation.
Preliminary animal experiment.
Artificial tracheae were implanted into rabbits with partial tracheal defects. Tracheal stenosis and regeneration of the tracheal epithelium on the artificial tracheae were evaluated by endoscopic examination, scanning electron microscopic analysis, and histological examination. The artificial tracheae fixed to the tracheal defects were classified into three groups (0-point, 4-point, and 8-point) by the number of fixation points.
At 14 and 28 days post-implantation, the luminal surface of the implantation area was mostly covered with epithelium in all fixation groups. However, a small amount of granulation tissue was observed in the 0-point fixation group at 14 days post-implantation. Moreover, tracheal stenosis did not occur in the 8-point fixation group, but stenosis was detected in the other groups.
人工气管的牢固固定对于上皮化和气管狭窄至关重要。
作者研发了一种人工气管并将其用于气管重建。尽管已经开展了各种关于气管重建的研究，但尚无研究探讨人工气管固定对气管狭窄和再生的影响。因此，本研究的目的是评估人工气管固定的效果。
初步动物实验。
将人工气管植入有部分气管缺损的兔子体内。通过内镜检查、扫描电子显微镜分析和组织学检查评估人工气管上的气管狭窄和气管上皮再生情况。根据固定点的数量，将固定于气管缺损处的人工气管分为三组（0点、4点和8点）。
植入后14天和28天，所有固定组植入区域的管腔表面大多被上皮覆盖。然而，在植入后14天，0点固定组观察到少量肉芽组织。此外，8点固定组未发生气管狭窄，但其他组检测到狭窄。
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