Karsy Michael, Hawryluk Gregory
Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
Department of Neurosurgery, University of Utah, Salt Lake City, UT, USA.
Neurosurg Clin N Am. 2017 Jan;28(1):49-62. doi: 10.1016/j.nec.2016.07.002.
Spinal cord injury is a serious global public health problem that often leaves patients with devastating permanent disabilities. Although advances in supportive care have improved outcome in recent decades, there remains great need for a safe and efficacious medical treatment that improves neurologic outcome. This article reviews pharmacologic treatments evaluated or in the process of development in humans. Cellular transplantation strategies are briefly reviewed especially where they have been evaluated with pharmacologic treatments. There is great hope that one or more of these new therapeutics will be successfully translated and improve the neurologic recovery of patients in the near future.
脊髓损伤是一个严重的全球性公共卫生问题,常常使患者遭受毁灭性的永久性残疾。尽管近几十年来支持性护理的进展改善了治疗结果,但仍迫切需要一种安全有效的医学治疗方法来改善神经学预后。本文综述了已在人体中进行评估或正在研发过程中的药物治疗方法。细胞移植策略也将简要回顾,特别是那些与药物治疗联合评估的策略。人们寄厚望于这些新疗法中的一种或多种能够成功转化应用,并在不久的将来改善患者的神经功能恢复。