HLA - DRw52等位基因系列三个成员的结构与T细胞反应的相关性。
Correlation of structure with T cell responses of the three members of the HLA-DRw52 allelic series.
作者信息
Gorski J, Irle C, Mickelson E M, Sheehy M J, Termijtelen A, Ucla C, Mach B
机构信息
Department of Microbiology, University of Geneva Medical School, Switzerland.
出版信息
J Exp Med. 1989 Sep 1;170(3):1027-32. doi: 10.1084/jem.170.3.1027.
Abstract
A third allele at the DRB3 locus, DRw52c, represents an intermediate sequence between DRw52a and DRw52b and may have arisen by a gene conversion-like event. The recognition of cells bearing these molecules by a number of alloreactive and antigen-specific DR-restricted T cell clones was analyzed. On the basis of a theoretical model of HLA class II structure, distinct amino acid clusters have been identified as motifs controlling TCR recognition. These are located both in the cleft and in the alpha-helical edge of the MHC class II recognition platform. Motifs shared between two alleles may restrict public T cell clones.
摘要
DRB3基因座上的第三个等位基因DRw52c，代表DRw52a和DRw52b之间的中间序列，可能是由类似基因转换的事件产生的。分析了许多同种异体反应性和抗原特异性DR限制性T细胞克隆对携带这些分子的细胞的识别情况。基于HLA II类结构的理论模型，已确定不同的氨基酸簇为控制TCR识别的基序。这些基序位于MHC II类识别平台的裂隙和α螺旋边缘。两个等位基因之间共享的基序可能会限制公共T细胞克隆。
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