Ohtsubo Y, Furukawa M, Fujinobu Y, Sugimoto N, Ikutoh M, Katoh Y, Yano I, Higasa M, Shinka S, Dohi Y
Nihon Saikingaku Zasshi. 1989 Mar;44(2):533-9. doi: 10.3412/jsb.44.533.
A mycolic acid-containing glycolipid, trehalose-2,3,6'-trimycolate (GaGM), derived from Gordona aurantiaca, an acid-fast bacterium closely related taxonomically to Mycobacterium, was investigated for its immune adjuvant activity on cell-mediated responses in the mouse. I.V. injection of liposomes containing GaGM enhanced the generation of cytotoxic T-lymphocyte (CTL) against syngeneic and allogeneic tumor cells. In addition, the injection of GaGM augmented the natural killer (NK) activity and the antibody-dependent cellular cytotoxicity (ADCC). These results suggest that the injection of GaGM induces the production of interleukin-2 (IL-2), since such effector cells as CTL, NK and K cells have been shown to require IL-2 for their development.
一种含分枝菌酸的糖脂，海藻糖-2,3,6'-三分枝菌酸酯（GaGM），来源于戈登氏菌，一种在分类学上与分枝杆菌密切相关的抗酸细菌，对其在小鼠细胞介导反应中的免疫佐剂活性进行了研究。静脉注射含GaGM的脂质体增强了针对同基因和异基因肿瘤细胞的细胞毒性T淋巴细胞（CTL）的生成。此外，注射GaGM增强了自然杀伤（NK）活性和抗体依赖性细胞毒性（ADCC）。这些结果表明，注射GaGM可诱导白细胞介素-2（IL-2）的产生，因为诸如CTL、NK和K细胞等效应细胞已被证明其发育需要IL-2。
