自由流动中剪切力介导的血小板活化：介导心血管植入物血栓形成的细胞力学生物学机制新进展的视角
Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis.
作者信息
Slepian Marvin J, Sheriff Jawaad, Hutchinson Marcus, Tran Phat, Bajaj Naing, Garcia Joe G N, Scott Saavedra S, Bluestein Danny
机构信息
Departments of Medicine and Biomedical Engineering, University of Arizona, Tucson, AZ 85721, United States; Department of Biomedical Engineering, Stony Brook University, NY 11794, United States.
Department of Biomedical Engineering, Stony Brook University, NY 11794, United States.
出版信息
J Biomech. 2017 Jan 4;50:20-25. doi: 10.1016/j.jbiomech.2016.11.016. Epub 2016 Nov 10.
Abstract
Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for "free flow" activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.
摘要
剪切力介导的血小板激活（SMPA）在可植入心血管治疗设备的血栓形成中起核心作用。尽管这些设备的血栓形成会带来发病率和死亡率，但我们对SMPA中起作用的机制，尤其是在自由流动血液中的机制的理解仍然有限。在此，我们提出并讨论一系列新出现的机制，以供考虑在超生理剪切力下的“自由流动”激活。对这些机制的进一步定义和操控将为限制SMPA和提高整体植入设备安全性的新型药理学和机械策略提供机会。
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