Magnusson A, Höglund U, Sjöquist M
Department of Medical Pharmacology, Biomedical Centre, Uppsala, Sweden.
Neurosci Lett. 1989 Jul 3;101(3):281-7. doi: 10.1016/0304-3940(89)90546-6.
Discrete brain structures were analysed for gamma-aminobutyric acid (GABA) and vasopressin content in normo- and hypotensive rats treated with the glutamic acid decarboxylase inhibitor, 3-mercaptopropionic acid (MPA) and the GABAA agonist muscimol. In the normotensive group treated with MPA only, the concentration of vasopressin increased in the supraoptic nucleus, indicating an inhibitory role for GABA. In the hypotensive group a rise in the vasopressin level in the nucleus of the solitary tract was detected and the GABA level decreased in the supraoptic nucleus. Muscimol decreased the concentration of vasopressin in the nucleus of the solitary tract. The changes in the concentration of vasopressin may be a result of increased or decreased activation of the GABAergic system. The results show that the GABA- and vasopressinergic systems somehow interact although the more precise way of action remains to be clarified.
对正常血压和低血压大鼠的离散脑结构进行了分析，这些大鼠用谷氨酸脱羧酶抑制剂3-巯基丙酸（MPA）和GABAA激动剂蝇蕈醇处理，以检测γ-氨基丁酸（GABA）和加压素的含量。在仅用MPA处理的正常血压组中，视上核中加压素的浓度增加，表明GABA具有抑制作用。在低血压组中，检测到孤束核中加压素水平升高，视上核中GABA水平降低。蝇蕈醇降低了孤束核中加压素的浓度。加压素浓度的变化可能是GABA能系统激活增加或减少的结果。结果表明，GABA能系统和加压素能系统以某种方式相互作用，尽管更精确的作用方式仍有待阐明。
