Walgama Evan S, Hwang Peter H
Department of Otolaryngology/Head and Neck Surgery, Stanford School of Medicine, Stanford Sinus Center, 801 Welch Road, Palo Alto, CA 94304, USA.
Department of Otolaryngology/Head and Neck Surgery, Stanford School of Medicine, Stanford Sinus Center, 801 Welch Road, Palo Alto, CA 94304, USA.
Otolaryngol Clin North Am. 2017 Feb;50(1):83-94. doi: 10.1016/j.otc.2016.08.007.
Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, sinonasal polyposis, and aspirin intolerance. The hallmark of the disease is baseline overproduction of cysteinyl leukotrienes via the 5-lipoxygenase pathway, exacerbated by ingestion of aspirin. Patients with AERD have high rates of recidivistic polyposis following sinus surgery, although the improvement in quality of life following surgery is similar to aspirin-tolerant patients. The diagnosis is secured by a positive aspirin provocation test, usually administered by a medical allergist. Aspirin therapy is a unique treatment consideration for patients with AERD.
阿司匹林诱发的呼吸道疾病（AERD）的特征是哮喘、鼻息肉病和阿司匹林不耐受三联征。该疾病的标志是通过5-脂氧合酶途径基线半胱氨酰白三烯过度产生，因摄入阿司匹林而加剧。AERD患者鼻窦手术后息肉复发率很高，尽管手术后生活质量的改善与阿司匹林耐受患者相似。通过阿司匹林激发试验阳性来确诊，通常由医学过敏症专科医生进行。阿司匹林治疗是AERD患者一种独特的治疗考量。
