人类免疫缺陷病毒/艾滋病、人乳头瘤病毒与肛门癌。
Human Immunodeficiency Virus/AIDS, Human Papillomavirus, and Anal Cancer.
作者信息
Wang Chia-Ching J, Sparano Joseph, Palefsky Joel M
机构信息
Division of Hematology/Oncology, Department of Medicine, Zuckerberg San Francisco General Hospital, 995 Potrero Avenue, Building 80, 4th Floor, San Francisco, CA 94110, USA.
Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 1695 Eastchester Road, Bronx, NY 10461, USA.
出版信息
Surg Oncol Clin N Am. 2017 Jan;26(1):17-31. doi: 10.1016/j.soc.2016.07.010.
Abstract
Anal cancer is an increasingly common non-AIDS-defining cancer among individuals infected with the human immunodeficiency virus (HIV). It is associated with human papillomavirus (HPV). HPV16 is the most common genotype detected in anal cancers. The HPV types detected in anal cancer are included in the 9-valent vaccine. HPV vaccines have demonstrated efficacy in reducing anal precancerous lesions in HIV-infected individuals. Standard treatment has been fluorouracil and mitomycin (or cisplatin) plus radiation. Continued studies are needed to test new treatment strategies in HIV-infected patients with anal cancer to determine which treatment protocols provide the best therapeutic index.
摘要
肛门癌在感染人类免疫缺陷病毒（HIV）的个体中是一种越来越常见的非艾滋病定义性癌症。它与人乳头瘤病毒（HPV）有关。HPV16是在肛门癌中检测到的最常见基因型。在肛门癌中检测到的HPV类型包含在9价疫苗中。HPV疫苗已证明在减少HIV感染个体的肛门癌前病变方面有效。标准治疗方法是氟尿嘧啶和丝裂霉素（或顺铂）加放疗。需要持续开展研究，以测试针对感染HIV的肛门癌患者的新治疗策略，从而确定哪种治疗方案能提供最佳治疗指数。
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