1型糖尿病儿童及青少年的纵向生长

Longitudinal Growth in Children and Adolescents with Type 1 Diabetes.

作者信息

Parthasarathy Lavanya, Khadilkar Vaman, Chiplonkar Shashi, Khadilkar Anuradha

机构信息

Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. Correspondence to: Dr Anuradha Khadilkar, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32 Sassoon Road, Pune.411 001, India.

出版信息

Indian Pediatr. 2016 Nov 15;53(11):990-992. doi: 10.1007/s13312-016-0974-1.

DOI:10.1007/s13312-016-0974-1

PMID:27889727

Abstract

OBJECTIVE

To study longitudinal growth in children with type 1 diabetes mellitus.

METHODS

Anthropometry, disease duration, insulin regimens and HbA1C recorded from patients with diabetes enrolled in a specialty clinic.

RESULTS

160 children (75 boys; mean (SD) age 9.4 (3.3) y) were enrolled. 35% children had low (<25th centile) height velocity. Disease duration and HbA1C affected height velocity (adjusted for puberty). Children on basal-bolus had higher height velocity Z scores than those on a split mix regimen [(0.5(1.6) vs. -0.3(1.4), P<0.05)]. Children diagnosed before 5 years of age had lowest height velocity. Of the children who reached final height, 53% remained below target height.

CONCLUSION

Children with type 1 diabetes mellitus have lower height velocity compared to healthy children; those diagnosed at younger age were at higher risk for growth failure.

摘要

目的

研究1型糖尿病患儿的纵向生长情况。

方法

记录专科门诊中糖尿病患者的人体测量数据、病程、胰岛素治疗方案和糖化血红蛋白（HbA1C）。

结果

共纳入160名儿童（75名男孩；平均（标准差）年龄9.4（3.3）岁）。35%的儿童身高增长速度较低（低于第25百分位数）。病程和糖化血红蛋白影响身高增长速度（根据青春期进行调整）。采用基础-餐时胰岛素治疗方案的儿童身高增长速度Z评分高于采用混合胰岛素治疗方案的儿童[（0.5（1.6）对-0.3（1.4），P<0.05）]。5岁前确诊的儿童身高增长速度最低。在达到最终身高的儿童中，53%仍低于目标身高。