Parthasarathy Lavanya, Khadilkar Vaman, Chiplonkar Shashi, Khadilkar Anuradha
Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India. Correspondence to: Dr Anuradha Khadilkar, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, 32 Sassoon Road, Pune.411 001, India.
Indian Pediatr. 2016 Nov 15;53(11):990-992. doi: 10.1007/s13312-016-0974-1.
To study longitudinal growth in children with type 1 diabetes mellitus.
Anthropometry, disease duration, insulin regimens and HbA1C recorded from patients with diabetes enrolled in a specialty clinic.
160 children (75 boys; mean (SD) age 9.4 (3.3) y) were enrolled. 35% children had low (<25th centile) height velocity. Disease duration and HbA1C affected height velocity (adjusted for puberty). Children on basal-bolus had higher height velocity Z scores than those on a split mix regimen [(0.5(1.6) vs. -0.3(1.4), P<0.05)]. Children diagnosed before 5 years of age had lowest height velocity. Of the children who reached final height, 53% remained below target height.
Children with type 1 diabetes mellitus have lower height velocity compared to healthy children; those diagnosed at younger age were at higher risk for growth failure.
研究1型糖尿病患儿的纵向生长情况。
记录专科门诊中糖尿病患者的人体测量数据、病程、胰岛素治疗方案和糖化血红蛋白（HbA1C）。
共纳入160名儿童（75名男孩；平均（标准差）年龄9.4（3.3）岁）。35%的儿童身高增长速度较低（低于第25百分位数）。病程和糖化血红蛋白影响身高增长速度（根据青春期进行调整）。采用基础-餐时胰岛素治疗方案的儿童身高增长速度Z评分高于采用混合胰岛素治疗方案的儿童[（0.5（1.6）对-0.3（1.4），P<0.05）]。5岁前确诊的儿童身高增长速度最低。在达到最终身高的儿童中，53%仍低于目标身高。
与健康儿童相比，1型糖尿病患儿的身高增长速度较低；发病年龄较小的患儿生长发育迟缓风险较高。
