Shaikh Wajid, Riaz Musarrat, Askari Saima, Basit Abdul
Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, PAK.
Cureus. 2022 Feb 20;14(2):e22397. doi: 10.7759/cureus.22397. eCollection 2022 Feb.
Objective In this study, we aimed to determine the linear growth and final height in children/adolescents with type 1 diabetes mellitus (T1DM) at a tertiary care hospital. Methodology This observational study was conducted at the Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University, Karachi, Pakistan. All children/adolescents diagnosed with T1DM of either gender aged between 8-18 years visiting the outpatient department of BIDE were included after obtaining informed consent. A predesigned questionnaire was developed to record data. The Centers for Disease Control and Prevention (CDC) growth chart was plotted and growth velocity was checked every six months to observe the linear growth. The final height was compared with the targeted height of the respective participants. Results A total of 66 people participated in the study (24 males and 42 females); among them, the mean age at diagnosis was 11.17 ± 4.77 years, and the duration of diabetes [median (IQR)] at the first visit was one year (0-3). The mean age at menarche was noted to be 13.56 ± 1.41 years. The overall height [standard deviation score (SDS)] at the first visit was -0.62 ± 2.58 and it was -1.34 ± 0.94 at the last visit; the overall weight at the first visit (SDS) and at the last visit was -1.23 ± 2.77 and -1.14 ± 1.25 respectively. Furthermore, the overall mid-parental height was 160.9 5 ± 10.28 cm, and 50% of males and 85.7% of females achieved genetic target height with a significant difference between them (p = 0.002). Conclusion A large number of people with TIDM were not able to achieve their target height. Therefore, it is imperative to monitor metabolic control along with monitoring of growth in young people with T1DM.
目的 在本研究中，我们旨在确定一家三级护理医院中1型糖尿病（T1DM）儿童/青少年的线性生长情况和最终身高。方法 这项观察性研究在巴基斯坦卡拉奇巴凯医科大学巴凯糖尿病与内分泌研究所（BIDE）进行。在获得知情同意后，纳入了所有8至18岁、在BIDE门诊部就诊的确诊为T1DM的儿童/青少年，无论性别。设计了一份预先设计的问卷来记录数据。绘制了美国疾病控制与预防中心（CDC）生长图表，并每六个月检查一次生长速度以观察线性生长情况。将最终身高与各参与者的目标身高进行比较。结果 共有66人参与了研究（24名男性和42名女性）；其中，诊断时的平均年龄为11.17±4.77岁，首次就诊时糖尿病病程[中位数（四分位间距）]为1年（0 - 3年）。初潮的平均年龄为13.56±1.41岁。首次就诊时的总体身高[标准差评分（SDS）]为 -0.62±2.58，最后一次就诊时为 -1.34±0.94；首次就诊时和最后一次就诊时的总体体重（SDS）分别为 -1.23±2.77和 -1.14±1.25。此外，总体父母平均身高为160.95±10.28厘米，50%的男性和85.7%的女性达到了遗传目标身高，两者之间存在显著差异（p = 0.002）。结论 大量T1DM患者未能达到其目标身高。因此，对于T1DM青少年，在监测生长情况的同时监测代谢控制势在必行。
