Sit K H
Department of Anatomy, National University of Singapore, Kent Ridge.
Am J Hum Genet. 1989 Sep;45(3):388-400.
Detection bias in recessive ascertainment is generally considered to be confined in a narrow range between unbiased truncate ascertainment and single ascertainment, where methods of segregation analysis are established. While there are arguments for an extended range of analysis, a deflated detection progression below the unbiased level is still being considered as theoretical ground or ignored as sporadics. I show here a method of gauging the ascertainment levels of surveyed data in a geometric continuum. The method is valid for recessive segregation at any ascertainment level and in simplex or multiplex sibships of whatever degree of truncation. Four previously published surveys are used to show conformation with real data and the existence of detection trends spanning the range from the unsuspected very depressed bias level to the inflated level above single ascertainment.
隐性确认中的检测偏倚通常被认为局限于无偏截断确认和单一确认之间的狭窄范围内,在此范围内已经建立了分离分析方法。虽然有人主张扩大分析范围,但低于无偏水平的检测进展仍被视为理论依据或被视为偶发情况而被忽略。我在此展示一种在几何连续体中衡量调查数据确认水平的方法。该方法适用于任何确认水平下的隐性分离,以及任何截断程度的单重或多重同胞关系。使用四项先前发表的调查来证明与实际数据的一致性,以及存在从未被怀疑的极低偏差水平到高于单一确认的膨胀水平的检测趋势。