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The mode of inheritance of psoriasis: evidence for a major gene as well as a multifactorial component and its implication for genetic counselling.

作者信息

Iselius L, Williams W R

出版信息

Hum Genet. 1984;68(1):73-6. doi: 10.1007/BF00293877.

DOI:10.1007/BF00293877
PMID:6500559
Abstract

Complex segregation analysis of Lomholt's family data on psoriasis on the Faroe Islands gave evidence for an additive major gene with gene frequency of 0.07 and penetrance 0.12 and 0.44 in the heterozygote and in the homozygote, respectively. In addition, there was a multifactorial component with heritability 0.87. The implications of these findings for genetic counseling are discussed and analytical risk figures are presented for chosen pedigrees.

摘要

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本文引用的文献

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A genetic and statistical study of psoriasis.一项关于银屑病的遗传学与统计学研究。
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Inheritance of psoriasis in a Utah kindred.犹他州一个家族中银屑病的遗传情况。
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4
Probability calculations in pedigrees under complex modes of inheritance.复杂遗传模式下家系中的概率计算。
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The genetics of psoriasis.银屑病的遗传学
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Analysis of family resemblance. 3. Complex segregation of quantitative traits.家族相似性分析。3. 数量性状的复杂分离分析。
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9
On the genetics of psoriasis. An analysis of Hellgren's data for a model of multifactorial inheritance.关于银屑病的遗传学。对赫尔格伦多因素遗传模型数据的分析。
Arch Dermatol Forsch. 1973;247(1):53-8.
10
The inheritance of psoriasis.银屑病的遗传方式。
J Invest Dermatol. 1973 Jun;60(6):538-40. doi: 10.1111/1523-1747.ep12703617.