Molloy Eamonn S, Calabrese Cassandra M, Calabrese Leonard H
Department of Rheumatology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
RJ Fasenmeyer Center for Clinical Immunology, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Rheum Dis Clin North Am. 2017 Feb;43(1):95-109. doi: 10.1016/j.rdc.2016.09.009.
Progressive multifocal leukoencephalopathy (PML) is a rare, typically fatal, demyelinating central nervous system infection caused by reactivation of the John Cunningham virus that generally occurs in immunosuppressed patients. With an evolving understanding of a greater clinical heterogeneity of PML and significant implications for therapy, PML should be considered in the differential diagnosis of neurologic presentations of rheumatic diseases. Increased awareness of PML among rheumatologists is required, as earlier diagnosis and restoration of immune function may improve the otherwise grim prognosis associated with PML.
进行性多灶性白质脑病（PML）是一种罕见的、通常致命的中枢神经系统脱髓鞘感染，由约翰·坎宁安病毒再激活引起，一般发生在免疫抑制患者中。随着对PML临床异质性的认识不断深入以及其对治疗的重大影响，在风湿性疾病神经系统表现的鉴别诊断中应考虑PML。风湿科医生需要提高对PML的认识，因为早期诊断和恢复免疫功能可能改善PML原本严峻的预后。
