Barber Emma L, Clarke-Pearson Daniel L
University of North Carolina, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chapel Hill, NC, United States; Lineberger Clinical Cancer Center, University of North Carolina, Chapel Hill, NC, United States.
University of North Carolina, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Chapel Hill, NC, United States; Lineberger Clinical Cancer Center, University of North Carolina, Chapel Hill, NC, United States.
Gynecol Oncol. 2017 Feb;144(2):420-427. doi: 10.1016/j.ygyno.2016.11.036. Epub 2016 Nov 25.
Gynecologic oncology patients are at a high-risk of postoperative venous thromboembolism and these events are a source of major morbidity and mortality. Given the availability of prophylaxis regimens, a structured comprehensive plan for prophylaxis is necessary to care for this population. There are many prophylaxis strategies and pharmacologic agents available to the practicing gynecologic oncologist. Current venous thromboembolism prophylaxis strategies include mechanical prophylaxis, preoperative pharmacologic prophylaxis, postoperative pharmacologic prophylaxis and extended duration pharmacologic prophylaxis that the patient continues at home after hospital discharge. In this review, we will summarize the available pharmacologic prophylaxis agents and discuss currently used prophylaxis strategies. When available, evidence from the gynecologic oncology patient population will be highlighted.
妇科肿瘤患者术后发生静脉血栓栓塞的风险很高，这些事件是主要发病和死亡的原因。鉴于有预防方案可供选择，为该人群提供护理需要制定结构化的综合预防计划。对于执业妇科肿瘤学家来说，有许多预防策略和药物可用。目前的静脉血栓栓塞预防策略包括机械预防、术前药物预防、术后药物预防以及患者出院后在家继续进行的延长疗程药物预防。在本综述中，我们将总结现有的药物预防药物，并讨论目前使用的预防策略。如有可用信息，将重点介绍来自妇科肿瘤患者群体的证据。
