Símová J, Bubeník J, Voitenok N N, Gren E
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
Folia Biol (Praha). 1989;35(3):137-42.
Age-dependent decline of the anti-tumour efficacy of local IL-2 immunotherapy and chemoimmunotherapy utilizing human recombinant interleukin 2 and cyclophosphamide was investigated in B10 mice bearing syngeneic MC-induced sarcoma. Repeated peritumoral injections of rIL-2 substantially inhibited growth of transplantable MC-induced sarcomas in syngeneic young adult mice whereas no effect was observed in the aged mice. Chemoimmunotherapy of the MC-induced sarcomas in the young adult and in the aged mice treated with cyclophosphamide plus rIL-2 revealed that subthreshold doses of CY were capable of significantly potentiating the immunotherapeutic effect of rIL-2 in young adult mice but not in the aged mice.
在携带同基因MC诱导肉瘤的B10小鼠中，研究了使用人重组白细胞介素2和环磷酰胺的局部IL-2免疫疗法和化学免疫疗法的抗肿瘤功效的年龄依赖性下降。在同基因年轻成年小鼠中，瘤周重复注射rIL-2可显著抑制可移植的MC诱导肉瘤的生长，而在老年小鼠中未观察到效果。对年轻成年小鼠和老年小鼠中用环磷酰胺加rIL-2治疗的MC诱导肉瘤进行化学免疫疗法显示，亚阈值剂量的CY能够显著增强rIL-2在年轻成年小鼠中的免疫治疗效果，但在老年小鼠中则不然。
