Lotts Tobias, Agelopoulos Konstantin, Phan Ngoc Q, Loser Karin, Schmaus Gerhard, Luger Thomas A, Ständer Sonja
Department of Dermatology, University of Münster, Münster, Germany.
Department of Dermatology, Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
Exp Dermatol. 2017 Aug;26(8):739-742. doi: 10.1111/exd.13265. Epub 2017 Mar 16.
Chronic pruritus is difficult to treat. Current treatment options are frequently ineffective and new therapeutic approaches are urgently needed. Avenanthramides are active substances in oats that exhibit anti-inflammatory effects. Their potential to interrupt pruritus mechanisms was investigated in this study. It was found that the synthetic analog dihydroavenanthramide D (DHAvD) can interact with the neurokinin-1 receptor (NK1R) and inhibit mast cell degranulation. DHAvD also affects inflammatory processes and reduces secretion of the cytokine interleukin-6. Our findings indicate that DHAvD may act as a NK1R inhibitor and could be a promising candidate for topical treatments of chronic pruritus.
慢性瘙痒难以治疗。目前的治疗方法常常无效，迫切需要新的治疗方法。燕麦酰胺是燕麦中的活性物质，具有抗炎作用。本研究对其阻断瘙痒机制的潜力进行了调查。结果发现，合成类似物二氢燕麦酰胺D（DHAvD）可与神经激肽-1受体（NK1R）相互作用并抑制肥大细胞脱颗粒。DHAvD还影响炎症过程并减少细胞因子白细胞介素-6的分泌。我们的研究结果表明，DHAvD可能作为一种NK1R抑制剂，有望成为慢性瘙痒局部治疗的候选药物。
