Błachnio-Zabielska Agnieszka, Grycel Sławomir, Chacińska Marta, Zabielski Piotr
Zakład Higieny, Epidemiologii i Zaburzeń Metabolicznych, Uniwersytet Medyczny w Białymstoku; NZOZ Specjalistyczny Ośrodek Medyczny "SOMED" Poradnia Diabetologiczna, Łomża.
NZOZ Specjalistyczny Ośrodek Medyczny "SOMED" Poradnia Diabetologiczna, Łomża.
Postepy Hig Med Dosw (Online). 2016 Nov 14;70(0):1142-1149. doi: 10.5604/17322693.1224257.
Skeletal muscle is the main tissue responsible for insulin-stimulated glucose uptake. Consumption of a high-fat diet rich in saturated fats (HFD) and obesity are associated with accumulation of intramuscular lipids that leads to several disorders, e.g. insulin resistance (IRes) and type 2 diabetes (T2D). The mechanism underlying the induction of IRes is still unknown. It was speculated that accumulation of intramuscular triacylglycerols (TAG) is linked to induction of IRes. Now, research focuses on bioactive lipids: long-chain acyl-CoA (LCACoA), diacylglycerols (DAG) and ceramides (Cer). It has been demonstrated that accumulation of each of the above-mentioned lipid classes negatively affects the insulin signaling pathway. It is not clear which of those lipids play the most important role in HFD-induced skeletal muscle IRes. The aim of the present work is to present the current knowledge of the role of adipose tissue and excess of fatty acids in the induction of insulin resistance.
骨骼肌是负责胰岛素刺激的葡萄糖摄取的主要组织。食用富含饱和脂肪的高脂饮食（HFD）和肥胖与肌肉内脂质积累有关，这会导致多种疾病，如胰岛素抵抗（IRes）和2型糖尿病（T2D）。IRes诱导的潜在机制仍然未知。据推测，肌肉内三酰甘油（TAG）的积累与IRes的诱导有关。现在，研究集中在生物活性脂质：长链酰基辅酶A（LCACoA）、二酰甘油（DAG）和神经酰胺（Cer）。已经证明，上述每种脂质类别的积累都会对胰岛素信号通路产生负面影响。尚不清楚这些脂质中哪一种在HFD诱导的骨骼肌IRes中起最重要作用。本研究的目的是介绍目前关于脂肪组织和脂肪酸过量在胰岛素抵抗诱导中的作用的知识。
