Diemoz Paul C, Bravin Alberto, Sztrókay-Gaul Anikó, Ruat Marie, Grandl Susanne, Mayr Doris, Auweter Sigrid, Mittone Alberto, Brun Emmanuel, Ponchut Cyril, Reiser Maximilian F, Coan Paola, Olivo Alessandro
Department of Medical Physics and Biomedical Engineering, University College London, London, WC1E 6BT, UK.
Phys Med Biol. 2016 Dec 21;61(24):8750-8761. doi: 10.1088/1361-6560/61/24/8750. Epub 2016 Nov 28.
Since the breast is one of the most radiosensitive organs, mammography is arguably the area where lowering radiation dose is of the uttermost importance. Phase-based x-ray imaging methods can provide opportunities in this sense, since they do not require x-rays to be stopped in tissue for image contrast to be generated. Therefore, x-ray energy can be considerably increased compared to those usually exploited by conventional mammography. In this article we show how a novel, optimized approach can lead to considerable dose reductions. This was achieved by matching the edge-illumination phase method, which reaches very high angular sensitivity also at high x-ray energies, to an appropriate image processing algorithm and to a virtually noise-free detection technology capable of reaching almost 100% efficiency at the same energies. Importantly, while proof-of-concept was obtained at a synchrotron, the method has potential for a translation to conventional sources.
由于乳房是对辐射最敏感的器官之一，乳腺摄影术无疑是降低辐射剂量至关重要的领域。基于相位的X射线成像方法在这方面提供了机会，因为它们不需要X射线在组织中被吸收来产生图像对比度。因此，与传统乳腺摄影术通常使用的能量相比，X射线能量可以大幅提高。在本文中，我们展示了一种新颖的优化方法如何能够显著降低剂量。这是通过将在高X射线能量下也能达到非常高角度灵敏度的边缘照明相位方法与适当的图像处理算法以及在相同能量下能够达到近100%效率的几乎无噪声检测技术相匹配来实现的。重要的是，虽然在同步加速器上获得了概念验证，但该方法有转化为传统光源的潜力。
