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用于医学成像应用的混合微焦点X射线源的连续和脉冲发射模式表征

Characterization of Continuous and Pulsed Emission modes of a Hybrid Micro Focus X-ray Source for Medical Imaging Applications.

作者信息

Ghani Muhammad U, Wong Molly D, Ren Liqiang, Wu Di, Zheng Bin, Rong John X, Wu Xizeng, Liu Hong

机构信息

Center for Biomedical Engineering and School of Electrical and Computer Engineering, University of Oklahoma, Norman, OK, 73019, USA.

Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

出版信息

Nucl Instrum Methods Phys Res A. 2017 May 1;853:70-77. doi: 10.1016/j.nima.2017.02.030. Epub 2017 Feb 16.

Abstract

The aim of this study was to quantitatively characterize a micro focus x-ray tube that can operate in both continuous and pulsed emission modes. The micro focus x-ray source (Model L9181-06, Hamamatsu Photonics, Japan) has a varying focal spot size ranging from 16-50 μm as the source output power changes from 10-39 W. We measured the source output, beam quality, focal spot sizes, kV accuracy, spectra shapes and spatial resolution. Source output was measured using an ionization chamber for various tube voltages (kVs) with varying current (μA) and distances. The beam quality was measured in terms of half value layer (HVL), kV accuracy was measured with a non-invasive kV meter, and the spectra was measured using a compact integrated spectrometer system. The focal spot sizes were measured using a slit method with a CCD detector with a pixel pitch of 22 μm. The spatial resolution was quantitatively measured using the slit method with a CMOS flat panel detector with a 50 μm pixel pitch, and compared to the qualitative results obtained by imaging a contrast bar pattern. The focal spot sizes in the vertical direction were smaller than that of the horizontal direction, the impact of which was visible when comparing the spatial resolution values. Our analyses revealed that both emission modes yield comparable imaging performances in terms of beam quality, spectra shape and spatial resolution effects. There were no significantly large differences, thus providing the motivation for future studies to design and develop stable and robust cone beam imaging systems for various diagnostic applications.

摘要

本研究的目的是对一种可在连续和脉冲发射模式下运行的微焦点X射线管进行定量表征。微焦点X射线源(型号L9181 - 06,日本滨松光子学公司)随着源输出功率从10 - 39 W变化,其焦点尺寸在16 - 50μm范围内变化。我们测量了源输出、光束质量、焦点尺寸、千伏精度、光谱形状和空间分辨率。使用电离室在不同管电压(千伏)、不同电流(微安)和不同距离下测量源输出。根据半值层(HVL)测量光束质量,使用无创千伏计测量千伏精度,并使用紧凑型集成光谱仪系统测量光谱。使用带有像素间距为22μm的电荷耦合器件(CCD)探测器的狭缝法测量焦点尺寸。使用带有50μm像素间距的互补金属氧化物半导体(CMOS)平板探测器的狭缝法定量测量空间分辨率,并将其与通过对对比度条图案成像获得的定性结果进行比较。垂直方向的焦点尺寸小于水平方向,在比较空间分辨率值时,这种影响是可见的。我们的分析表明,就光束质量、光谱形状和空间分辨率影响而言,两种发射模式产生的成像性能相当。没有显著的大差异,因此为未来研究设计和开发用于各种诊断应用的稳定且强大的锥束成像系统提供了动力。

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