Huang Minghua, Guo Yong, Ye Qiong, Chen Lei, Zhou Kai, Wang Qingjun, Shao Lixin, Shi Qinglei, Chen Chun
Department of Orthopaedics, The First Affiliated Hospital, Wenzhou Medical University, Wenzou, Zhejiang Department of Radiology, Navy General Hospital, Beijing Department of Radiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzou, Zhejiang Siemens Ltd, China Healthcare Sector MR Business Group, Beijing, P.R. China.
Medicine (Baltimore). 2016 Nov;95(47):e4502. doi: 10.1097/MD.0000000000004502.
To demonstrate the potential benefits of T2 relaxation time of intervertebral discs (IVDs) regarding the detection and grading of degenerative disc disease using 3.0-T magnetic resonance imaging (MRI) in a clinical setting.
Cervical sagittal T2-weighted, T2 relaxation MRI was performed at 3.0-T in 61 subjects, covering discs C2-3 to C6-7. All discs were morphologically assessed based on the Pfirrmann grade, and regions of interests (ROIs) were drawn over the T2 mapping. Receiver operating characteristic (ROC) analysis was performed among grades to determine the cut-off values.
Cervical intervertebral discs (IVDs) of patients were commonly determined to be at Pfirrmann grades III to V. The nucleus pulposus (NP) values did not differ significantly between sexes at the same anatomic level (P > 0.05). In the NP, the T2 values tended to decrease with increasing grade (P < 0.000), and a significant difference was found in the T2 values between grades I to V (P < 0.05). T2 values based on disc degeneration level classification were as follows: grade I (>30 milliseconds), grade II (24.55-29.99 milliseconds), grade III (21.65-24.54 milliseconds), grade IV (18.35-21.64 milliseconds), and grade V (<18.34 milliseconds).
Our standardized method of region-specific quantitative T2 relaxation time evaluation seems capable of characterizing different degrees of disc degeneration quantitatively. The T2 values obtained in these cervical IVDs may serve as baseline values for future T2 measurements in both healthy and degenerated cervical discs.
在临床环境中，利用3.0-T磁共振成像（MRI）证明椎间盘（IVD）的T2弛豫时间在检测和分级椎间盘退变疾病方面的潜在益处。
对61名受试者进行3.0-T颈椎矢状面T2加权、T2弛豫MRI检查，覆盖C2-3至C6-7椎间盘。所有椎间盘均根据Pfirrmann分级进行形态学评估，并在T2映射上绘制感兴趣区域（ROI）。在各分级之间进行受试者操作特征（ROC）分析以确定临界值。
患者的颈椎间盘（IVD）通常被判定为Pfirrmann III至V级。在相同解剖水平上，男女之间髓核（NP）值无显著差异（P>0.05）。在NP中，T2值倾向于随分级增加而降低（P<0.000），并且在I至V级之间的T2值存在显著差异（P<0.05）。基于椎间盘退变程度分类的T2值如下：I级（>30毫秒），II级（24.55-29.99毫秒），III级（21.65-24.54毫秒），IV级（18.35-21.64毫秒），V级（<18.34毫秒）。
我们标准化的区域特异性定量T2弛豫时间评估方法似乎能够定量表征不同程度的椎间盘退变。在这些颈椎IVD中获得的T2值可作为未来健康和退变颈椎间盘T2测量的基线值。
