识别肌萎缩侧索硬化症中的行为变化：博蒙特行为量表（BBI）的验证
Identifying behavioural changes in ALS: Validation of the Beaumont Behavioural Inventory (BBI).
作者信息
Elamin Marwa, Pinto-Grau Marta, Burke Tom, Bede Peter, Rooney James, O'Sullivan Meabhdh, Lonergan Katie, Kirby Emma, Quinlan Emma, Breen Nadia, Vajda Alice, Heverin Mark, Pender Niall, Hardiman Orla
机构信息
a Academic Unit of Neurology, Trinity Biomedical Sciences Institute , Trinity College Dublin , Ireland.
b Department of Psychology , Beaumont Hospital , Dublin , Ireland.
出版信息
Amyotroph Lateral Scler Frontotemporal Degener. 2017 Feb;18(1-2):68-73. doi: 10.1080/21678421.2016.1248976. Epub 2016 Nov 28.
OBJECTIVE
Behavioural changes are an important part of amyotrophic lateral sclerosis (ALS). However, most tools do not account for the influence of motor impairment. Furthermore, they do not fully measure the broad range of behavioural changes specific to ALS. This study aimed to develop and validate an ALS specific behavioural inventory, the Beaumont Behavioural Inventory (BBI).
METHODS
The BBI was validated in a cohort of ALS patients (n = 85) and 78 age-, gender-, and education-matched controls. The scale was validated against the Frontal Systems Behaviour Scale (FrSBe) and The Frontal Assessment Battery (FAB) for convergent validity, and against other non-behavioural measures to assess discriminant validity. Reliability was assessed with Cronbach's alpha.
RESULTS
The instrument showed high internal consistency (Cronbach's alpha value =0.891). BBI scores highly correlated with the FrSBe and moderately with the FAB. However, the measure was independent from non-behavioural measures. Using a cut-off score of 7 for mild behavioural changes, the BBI displayed high sensitivity and specificity (87.9% and 78.85%, respectively). The cut-off score for moderate changes, consistent with a diagnosis of ALS-FTD, is set at 22.5, showing 90% sensitivity and 96% specificity.
DISCUSSION
The BBI is a sensitive and specific tool to assess the entire behavioural spectrum of ALS.
目的
行为改变是肌萎缩侧索硬化症（ALS）的重要组成部分。然而，大多数工具并未考虑运动障碍的影响。此外，它们并未全面衡量ALS特有的广泛行为改变。本研究旨在开发并验证一种针对ALS的行为量表，即博蒙特行为量表（BBI）。
方法
在一组ALS患者（n = 85）以及78名年龄、性别和教育程度相匹配的对照者中对BBI进行验证。该量表与额叶系统行为量表（FrSBe）和额叶评估量表（FAB）进行对照以验证收敛效度，并与其他非行为测量方法对照以评估区分效度。使用克朗巴哈系数评估信度。
结果
该工具显示出较高的内部一致性（克朗巴哈系数值 = 0.891）。BBI得分与FrSBe高度相关，与FAB中度相关。然而，该测量与非行为测量方法无关。对于轻度行为改变，使用截断分数7时，BBI显示出高敏感性和特异性（分别为87.9%和78.85%）。与ALS-额颞叶痴呆诊断一致的中度改变的截断分数设定为22.5，敏感性为90%，特异性为96%。
讨论
BBI是评估ALS整个行为谱的一种敏感且特异的工具。
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