Li Z, Zhong Q, Liu H, Liu P, Wu J, Ma D, Chen X, Yang X
Department of Neurosurgery, Mianyang Central Hospital, Sichuan, China.
Cell Mol Biol (Noisy-le-grand). 2016 Oct 31;62(12):68-73. doi: 10.14715/cmb/2016.62.12.12.
Malignant glioma is one of the most common brain tumors in the central nervous system. Although the significant progress has been made in recent years, the mortality is still high and 5-year survival rate is still very low. One of the leading causes to the high mortality for glioma patients is metastasis and invasion. An efficient method to control the tumor metastasis is a promising way to treat the glioma. Previous reports indicated that neural stem cells (NSCs) were served as a delivery vector to the anti-glioma therapy. Here, we used the conditioned medium from rat NSCs (NSC-CM) to culture the human glioblastoma cell lines. We found that NSC-CM could inhibit the glioma cell growth, invasion and migration in vitro and attenuate the tumor growth in vivo. Furthermore, this anti-glioma effect was mediated by the inactivation of mitogen activated protein kinase (MAPK) pathway. Above all, this study provided the direct evidence to put forward a simple and efficient method in the inhibition of glioma cells/tumor growth, potentially advancing the anti-glioma therapy.
恶性胶质瘤是中枢神经系统中最常见的脑肿瘤之一。尽管近年来取得了显著进展，但死亡率仍然很高，5年生存率仍然很低。胶质瘤患者高死亡率的主要原因之一是转移和侵袭。一种控制肿瘤转移的有效方法是治疗胶质瘤的有前景的途径。先前的报道表明，神经干细胞（NSCs）可作为抗胶质瘤治疗的递送载体。在此，我们使用大鼠神经干细胞条件培养基（NSC-CM）培养人胶质母细胞瘤细胞系。我们发现NSC-CM在体外可抑制胶质瘤细胞的生长、侵袭和迁移，并在体内减弱肿瘤生长。此外，这种抗胶质瘤作用是由丝裂原活化蛋白激酶（MAPK）通路的失活介导的。最重要的是，本研究提供了直接证据，提出了一种简单有效的抑制胶质瘤细胞/肿瘤生长的方法，有可能推动抗胶质瘤治疗的发展。
