Nishita Yukiko, Tange Chikako, Tomida Makiko, Otsuka Rei, Ando Fujiko, Shimokata Hiroshi
Section of National Institute for Longevity Sciences - Longitudinal Study of Aging (NILS-LSA), National Center for Geriatrics and Gerontology, Aichi, Japan.
Section of National Institute for Longevity Sciences - Longitudinal Study of Aging (NILS-LSA), National Center for Geriatrics and Gerontology, Aichi, Japan.
J Psychosom Res. 2016 Dec;91:20-25. doi: 10.1016/j.jpsychores.2016.10.004. Epub 2016 Oct 14.
To examine the longitudinal associations between the big five personality and changes in global cognitive function among community-dwelling elderly people involved in the National Institute for Longevity Sciences - Longitudinal Study of Aging.
The participants were 594 individuals (age range 60-81years) and followed for 10years and tested six times. Personality was assessed by the Japanese version of NEO five factor inventory at baseline. Cognitive function was assessed by the Japanese version of Mini Mental State Examination (MMSE) at all visits. For participants with a baseline MMSE score≥28, logistic generalized estimating equation models estimated the odds ratio (OR) and 95% confidence interval (CI) for MMSE score≤27 at each follow-up visit, according to a 1-SD increase of the baseline personality score. Post hoc analyses were performed for mild cognitive deficits, baseline MMSE score≥24 and ≤27, to estimate the OR and CI for MMSE score≤23.
The adjusted OR for MMSE score≤27 was 0.78 (95% CI, 0.69-0.88), with a 1-SD increase in Openness to Experience score. In post hoc analyses, the adjusted OR for MMSE score≤23 was 0.50 (95% CI, 0.35-0.72) with a 1-SD increase in Conscientiousness score. Relationships between other personality traits and the decline in MMSE score were not significant.
Higher Openness to Experience was associated with a reduction in risk for cognitive decline in community-dwelling older adults. Higher Conscientiousness might also predict lower risk for severe cognitive decline, especially for individuals with mild cognitive deficits.
在参与国立长寿科学研究所-衰老纵向研究的社区老年人中，研究大五人格与全球认知功能变化之间的纵向关联。
参与者为594人（年龄范围60-81岁），随访10年，进行了6次测试。在基线时通过日本版的NEO五因素问卷评估人格。在每次访视时通过日本版简易精神状态检查表（MMSE）评估认知功能。对于基线MMSE评分≥28的参与者，逻辑广义估计方程模型根据基线人格评分每增加1个标准差，估计每次随访时MMSE评分≤27的比值比（OR）和95%置信区间（CI）。对轻度认知缺陷、基线MMSE评分≥24且≤27的情况进行事后分析，以估计MMSE评分≤23的OR和CI。
经验开放性得分每增加1个标准差，MMSE评分≤27的校正OR为0.78（95%CI，0.69-0.88）。在事后分析中，尽责性得分每增加1个标准差，MMSE评分≤23的校正OR为0.50（95%CI，0.35-0.72）。其他人格特质与MMSE评分下降之间的关系不显著。
较高的经验开放性与社区居住的老年人认知衰退风险降低有关。较高的尽责性也可能预示着严重认知衰退的风险较低，尤其是对于有轻度认知缺陷的个体。
