Hawksworth Owen A, Coulthard Liam G, Woodruff Trent M
School of Biomedical Sciences, University of Queensland, St. Lucia, Australia; Australian Institute of Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Australia.
School of Medicine, University of Queensland, Herston, Australia; Royal Brisbane and Women's Hospital, Herston, Australia.
Mol Immunol. 2017 Apr;84:17-25. doi: 10.1016/j.molimm.2016.11.010. Epub 2016 Nov 25.
Once regarded solely as an activator of innate immunity, it is now clear that the complement system acts in an assortment of cells and tissues, with immunity only one facet of a diverse array of functions under the influence of the complement proteins. Throughout development, complement activity has now been demonstrated from early sperm-egg interactions in fertilisation, to regulation of epiboly and organogenesis, and later in refinement of cerebral synapses. Complement has also been shown to regulate homeostasis of adult tissues, controlling cell processes such as migration, survival, repair, and regeneration. Given the continuing emergence of such novel actions of complement, the existing research likely represents only a fraction of the myriad of functions of this complex family of proteins. This review is focussed on outlining the current knowledge of complement family members in the regulation of cell processes in non-immune systems. It is hoped this will spur research directed towards revealing more about the role of complement in these fundamental cell processes.
补体系统曾经仅被视为先天免疫的激活剂，现在很清楚的是，它在多种细胞和组织中发挥作用，免疫只是在补体蛋白影响下的一系列多样功能中的一个方面。在整个发育过程中，现已证明补体活性从受精时早期的精卵相互作用，到外包和器官发生的调节，以及后来在脑突触的细化过程中都有体现。补体还被证明可调节成体组织的稳态，控制细胞迁移、存活、修复和再生等过程。鉴于补体这种新作用不断出现，现有研究可能仅代表了这个复杂蛋白质家族无数功能的一小部分。本综述着重概述补体家族成员在非免疫系统细胞过程调节方面的当前知识。希望这将推动旨在揭示补体在这些基本细胞过程中更多作用的研究。
