Sinha Mohita, Tripathi Tulika, Rai Priyank, Gupta Santosh Kumar
Postgraduate student, Department of Orthodontics and Dentofacial Orthopaedics, Maulana Azad Institute of Dental Sciences, New Delhi, India.
Professor and head, Department of Orthodontics and Dentofacial Orthopaedics, Maulana Azad Institute of Dental Sciences, New Delhi, India.
Am J Orthod Dentofacial Orthop. 2016 Dec;150(6):1020-1027. doi: 10.1016/j.ajodo.2016.04.028.
Biochemical markers are agents directly involved in bone growth and remodeling and can be quantitatively evaluated from various biologic fluids. The aim of this study was to assess the changes in the levels of insulin-like growth factor-1 (IGF-1) in serum and urine as a growth maturity indicator and to compare them with the cervical vertebral maturation radiographic stages.
The study was conducted with 72 female subjects aged 8 to 20 years. Cervical vertebral maturation stages, and serum and urine IGF-1 levels were recorded for all subjects, and the subjects were equally divided into the 6 cervical vertebral maturation groups. Median values of IGF-1 for each stage of cervical vertebral maturation were calculated and statistically compared with those of the other stages.
The levels of serum and urine IGF-1 at stage 4 of cervical vertebral maturation were significantly higher than those from the other stages (P <0.01). Stage 4 corresponded to a mean age of 13.67 years. A significant correlation was observed between serum and urine IGF-1 (P <0.001).
Urine IGF-1 follows the growth curve similar to serum IGF-1. Thus, urine IGF-1 may be regarded as a promising noninvasive tool for growth assessment. Further research is necessary to validate these results in a different population and with a larger sample.
生化标志物是直接参与骨骼生长和重塑的物质，可从各种生物体液中进行定量评估。本研究的目的是评估血清和尿液中胰岛素样生长因子-1（IGF-1）水平作为生长成熟指标的变化，并将其与颈椎成熟度的影像学分期进行比较。
该研究对72名年龄在8至20岁的女性受试者进行。记录所有受试者的颈椎成熟度分期以及血清和尿液IGF-1水平，并将受试者平均分为6个颈椎成熟度组。计算每个颈椎成熟度阶段IGF-1的中位数，并与其他阶段进行统计学比较。
颈椎成熟度第4阶段的血清和尿液IGF-1水平显著高于其他阶段（P<0.01）。第4阶段对应的平均年龄为13.67岁。血清和尿液IGF-1之间存在显著相关性（P<0.001）。
尿液IGF-1遵循与血清IGF-1相似的生长曲线。因此，尿液IGF-1可被视为一种有前景的用于生长评估的非侵入性工具。有必要进行进一步研究，以在不同人群和更大样本中验证这些结果。
