Department of Orthodontics and Dentofacial Orthopaedics, Maulana Azad Institute of Dental Sciences, Bahadur Shah Zafar Marg, New Delhi, 110002, India.
Prog Orthod. 2021 Sep 6;22(1):26. doi: 10.1186/s40510-021-00372-6.
Detection of skeletal maturity is vital in orthodontic treatment timing and planning. Traditional methods include hand-wrist radiography and cervical vertebral maturation index (CVMI). Though the radiographic methods are well established and routinely used to assess skeletal maturation, they carry the drawback of subjective perception and low reproducibility. With evolving concepts, skeletal maturation has been assessed quantitatively through biomarkers obtained from saliva, gingival crevicular fluid (GCF), and urine. The scoping review aims to explore the various biomarkers assessed through non-invasive methods and their correlation with radiographic skeletal maturity.
The literature search was carried out on MEDLINE via Pubmed, Cochrane Library (Cochrane database of systematic reviews), Cochrane central register of controlled trials (CENTRAL), Google Scholar, Semantic Scholar, ScienceDirect, and Opengrey.eu for articles up to and including November 2020. Pertinent articles were selected based on inclusion and exclusion criteria. The results were tabulated based on the type of sample collected, the biomarker assessed, method of sample collection, and the radiographic method used.
The literature search resulted in 12 relevant articles. Among all the studies, 10 studies showed that the concentration of biomarkers increases during the pubertal growth peak. On the contrary, 2 articles showed no significant difference between the levels of biomarkers and pubertal growth peak.
It can be concluded that the level of biomarkers increases during the pubertal growth spurt and can provide a quantitative way of assessing skeletal maturity.
在正畸治疗时机和计划中，骨骼成熟度的检测至关重要。传统方法包括手-腕部 X 光片和颈椎成熟度指数（CVMI）。虽然放射学方法已经确立并常规用于评估骨骼成熟度，但它们存在主观感知和低重现性的缺点。随着概念的不断发展，通过从唾液、龈沟液（GCF）和尿液中获得的生物标志物，已经对骨骼成熟度进行了定量评估。本综述旨在探讨通过非侵入性方法评估的各种生物标志物及其与放射学骨骼成熟度的相关性。
通过 MEDLINE 上的 Pubmed、Cochrane 图书馆（Cochrane 系统评价数据库）、Cochrane 中心对照试验注册（CENTRAL）、Google Scholar、Semantic Scholar、ScienceDirect 和 Opengrey.eu 进行文献检索，检索时间截至 2020 年 11 月。根据纳入和排除标准选择相关文章。结果根据收集的样本类型、评估的生物标志物、样本采集方法和使用的放射学方法进行列表。
文献检索共得到 12 篇相关文章。在所有研究中，有 10 项研究表明生物标志物的浓度在青春期生长高峰期增加。相反，有 2 篇文章显示生物标志物水平与青春期生长高峰期之间没有显著差异。
可以得出结论，生物标志物的水平在青春期生长突增期间增加，并可以提供一种定量评估骨骼成熟度的方法。
