Stein Paul D, Matta Fadi, Hughes Mary J
Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing.
Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing.
Am J Med. 2017 May;130(5):596-600. doi: 10.1016/j.amjmed.2016.10.030. Epub 2016 Nov 25.
Little is known about the in-hospital mortality of deep venous thrombosis in recent years. This investigation was undertaken to determine trends in in-hospital mortality in patients with deep venous thrombosis and mortality according to age.
Administrative data were analyzed from the National (Nationwide) Inpatient Sample, 2003-2012. We determined in-hospital all-cause mortality according to year and age among patients with a primary (first-listed) diagnosis of deep venous thrombosis. We analyzed all such patients and we analyzed those who had none of the comorbid conditions listed in the Charlson Comorbidity Index.
From 2003-2012, 1,603,690 hospitalized patients had a primary diagnosis of deep venous thrombosis. All-cause in-hospital mortality decreased from 1.3% in 2003 to 0.6% in 2012. Mortality increased with age from 0.1% in those aged 18-20 years to 1.5% in those over age 80 years. All-cause in-hospital mortality in those with no comorbid conditions according to the Charlson Comorbidity Index (1,094,184 patients) decreased from 1.1% in 2003 to 0.5% in 2012. Presumably, these deaths were from pulmonary embolism. All-cause mortality in those with no comorbid conditions increased with age from 0.1% in those aged 18-20 years to 1.4% in those over aged 80 years.
All-cause death and death due to pulmonary embolism in patients hospitalized with a primary diagnosis of deep venous thrombosis decreased from 2003-2012. The death rate increased with age. The decreased mortality over the period of investigation may have resulted from a shift toward use of low-molecular-weight heparins and newer anticoagulants.
近年来，关于深静脉血栓形成的院内死亡率了解甚少。本研究旨在确定深静脉血栓形成患者的院内死亡率趋势以及按年龄划分的死亡率。
分析了2003 - 2012年全国住院患者样本的管理数据。我们根据年份和年龄确定了原发性（首位列出）诊断为深静脉血栓形成患者的全因院内死亡率。我们分析了所有此类患者，并分析了那些没有Charlson合并症指数中列出的任何合并症的患者。
2003 - 2012年期间，1,603,690名住院患者的原发性诊断为深静脉血栓形成。全因院内死亡率从2003年的1.3%降至2012年的0.6%。死亡率随年龄增长而增加，从18 - 20岁患者的0.1%增至80岁以上患者的1.5%。根据Charlson合并症指数没有合并症的患者（1,094,184名患者）的全因院内死亡率从2003年的1.1%降至2012年的0.5%。据推测，这些死亡是由肺栓塞导致的。没有合并症的患者的全因死亡率随年龄增长，从18 - 20岁患者的0.1%增至80岁以上患者的1.4%。
2003 - 2012年期间，原发性诊断为深静脉血栓形成的住院患者的全因死亡和肺栓塞导致的死亡有所下降。死亡率随年龄增长而增加。调查期间死亡率的下降可能是由于向使用低分子量肝素和新型抗凝剂的转变。
