阿尔茨海默病中的血脑屏障。

The blood brain barrier in Alzheimer's disease.

作者信息

Chakraborty A, de Wit N M, van der Flier W M, de Vries H E

机构信息

Blood-brain barrier research group, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, P.O. Box 7057, 1007, MB Amsterdam, The Netherlands.

出版信息

Vascul Pharmacol. 2017 Feb;89:12-18. doi: 10.1016/j.vph.2016.11.008. Epub 2016 Nov 25.

DOI:10.1016/j.vph.2016.11.008

PMID:27894893

Abstract

Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people worldwide. One of the prominent causative factors of AD pathogenesis is cerebral vascular dysfunction, which results in diminished cerebral perfusion. Moreover, due to the loss of the protective function of the blood-brain barrier (BBB), impaired clearance of excess neurotoxic amyloid beta (Aβ) occurs, causing vascular perturbation and diminished cognitive functioning. The relationship between the prevalence of AD and vascular risk factors is complex and not fully understood. In this review we illustrate the vascular risk factors, their effects on BBB function and their contributions to the onset of AD. Additionally, we discuss the underlying factors that may lead to altered neurovascular function and/or cerebral hypoperfusion in AD.

摘要

阿尔茨海默病（AD）是最常见的痴呆形式，影响着全球数百万人。AD发病机制的一个突出致病因素是脑血管功能障碍，这会导致脑灌注减少。此外，由于血脑屏障（BBB）保护功能的丧失，过量神经毒性淀粉样蛋白β（Aβ）的清除受损，导致血管紊乱和认知功能下降。AD患病率与血管危险因素之间的关系复杂且尚未完全了解。在本综述中，我们阐述了血管危险因素、它们对BBB功能的影响以及它们对AD发病的作用。此外，我们还讨论了可能导致AD中神经血管功能改变和/或脑灌注不足的潜在因素。