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尽管阿奇霉素对伤寒沙门菌血清型伤寒杆菌的最低抑菌浓度较低，但仍出现阿奇霉素治疗临床和微生物学失败的病例。

A case of clinical and microbiological failure of azithromycin therapy in Salmonella enterica serotype Typhi despite low azithromycin MIC.

作者信息

Manesh Abi, Balaji Veeraraghavan, Kumar Devanga Ragupathi Naveen, Rupali Priscilla

机构信息

Department of Infectious Diseases, Christian Medical College, Vellore, India.

Department of Clinical Microbiology, Christian Medical College, Vellore, India.

出版信息

Int J Infect Dis. 2017 Jan;54:62-63. doi: 10.1016/j.ijid.2016.11.409. Epub 2016 Nov 25.

DOI:10.1016/j.ijid.2016.11.409
PMID:27894983
Abstract

Typhoid fever remains a serious problem in many developing countries. Due to resistance to multiple first line drugs, azithromycin has evolved as an important drug in the treatment of typhoid. While therapy with azithromycin is highly effective, no clinically validated mean inhibitory concentration (MIC) break points or disc diffusion cutoff guidelines are available so far. We describe an Indian adult with clinical and microbiological failure to azithromycin despite low azithromycin MIC.

摘要

伤寒热在许多发展中国家仍然是一个严重问题。由于对多种一线药物产生耐药性，阿奇霉素已成为治疗伤寒的一种重要药物。虽然阿奇霉素治疗非常有效，但目前尚无经过临床验证的最低抑菌浓度（MIC）断点或纸片扩散法截断值指南。我们描述了一名印度成年人，尽管阿奇霉素的MIC较低，但对阿奇霉素治疗仍出现临床和微生物学治疗失败的情况。

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